Molecular characterization of the dopamine transporter

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Abstract

Neurotransmission, which represents chemical signalling between neurons, usually takes place at highly differentiated anatomical structures called synapses. To fulfill both the time and space confinements required for optimal neurotransmission, highly specialized proteins, known as transporters or uptake sites, occur and operate at the presynaptic plasma membrane. Using the energy provided by the Na+ gradient generated by the Na+/K+ transporting ATPase, these transporters reuptake the neurotransmitters soon after their release, thereby regulating their effective concentrations at the synoptic cleft and the availability of neurotransmitters for a time-dependent activation of both pre- and postsynaptic receptors. The key role these proteins play in normal neurotransmission is further emphasized when the physiological and social consequences of drugs that interfere with the function of these transporters, such as the psyciwstimulants (e.g. amphetamine and cocaine) or the widely prescribed antidepressant drugs, are considered. In this review. Bruno Giros and Marc Caron elaborate on the potential consequences of the recent molecular cloning of the dopamine and related transporters and summarize some of the interesting properties that are emerging from this growing family of Na+- and Cl-dependent transporters.

References (45)

  • D.R. Sibley et al.

    Trends Pharmacol. Sci.

    (1992)
  • B. Giros et al.

    FEBS Lett.

    (1991)
  • Y. Liu

    Cell

    (1992)
  • R.T. Fremeau et al.

    Neuron

    (1992)
  • A. Yamauchi

    J. Biol. Chem.

    (1992)
  • K.E. Smith et al.

    Neuron

    (1992)
  • Q-R. Liu et al.

    FEBS Lett.

    (1992)
  • W. Mayser et al.

    FEBS Lett.

    (1992)
  • B.I. Kanner

    Biochim. Biophys. Acta

    (1983)
  • D.R. Cool et al.

    J. Biol. Chem.

    (1991)
  • A.S Horn

    Progr. Neurobiol.

    (1990)
  • J.A. Clark et al.

    Neuron

    (1992)
  • B. Lopez-Corcuera et al.

    J. Biol. Chem.

    (1992)
  • J. Delay et al.

    Ann. Med. Psychol.

    (1952)
  • T.J. Crow

    Experientia

    (1982)
  • S.H. Snyder

    Am. J. Psychiatry

    (1973)
  • J. Axelrod

    Recent Prog. Hormone Res.

    (1965)
  • J.A. Gingrich et al.

    Annu. Rev. Neurosci.

    (1993)
  • J.E. Kilty et al.

    Science

    (1991)
  • S. Shimada

    Science

    (1991)
  • T.B. Usdin et al.
  • B. Giros

    Mol. Pharmacol.

    (1992)
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