Nuclear magnetic resonance studies of the solution chemistry of metal complexes. 26. Mixed ligand complexes of cadmium, nitrilotriacetic acid, glutathione, and related ligands
References (28)
- et al.
Environ. Res.
(1971) - et al.
Biochim. Biophys. Acta.
(1983) - et al.
J. Inorg. Nucl. Chem.
(1965) - et al.
J. Inorg. Biochem.
(1983) JAMA
(1966)- et al.
Bull. Pathol.
(1967) - et al.
Am. J. Physiol.
(1965) - et al.
Bull. Pathol.
(1967) Bull. Environ. Contam. Toxicol.
(1979)
Bull. Environ. Contam. Toxicol.
Bull. Environ. Contam. Toxicol.
Bull. Environ. Contam. Toxicol.
Bull. Environ. Contam. Toxicol.
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Binding of cadmium dication to glutathione facilitates cysteine SH deprotonation: A computational DFT study
2013, Journal of Inorganic BiochemistryDetermination of stability constants of Cu(I), Cd(II) & Zn(II) complexes with thiols using fluorescent probes
2013, Journal of Inorganic BiochemistryCitation Excerpt :HEPES has been shown to be slightly reactive with copper [36] which may explain the slight difference between values. To establish and test our methodology of stability constant determination using fluorescent indicators, we first performed a set of titrations on complexes of Cd(II) and Zn(II) with GSH, which have been thoroughly investigated using various techniques [5,25,26,37–42]. Published stability constants for Cd(II)-GSH were used to predict metal speciation at each pH in order to select an appropriate indicator and optimize concentrations of metal and ligand.
Cadmium is a catalytic inhibitor of DNA topoisomerase II
2011, Journal of Inorganic BiochemistryCitation Excerpt :We and others have shown that the activity of topoisomerase IIα is highly sensitive to thiol-reactive compounds such as acrylamide [7], selenium compounds [8], maleimide [9], cisplatin [10], the organic mercury compound thimerosal [11] and quinones [12–15]. Given the high affinity of Cd2+ for thiols [16,17] we decided to investigate whether Cd2+ may, in part, be exerting its cytotoxicity by inhibiting DNA topoisomerase IIα through reaction with its free cysteine thiol groups. We showed in an earlier mass spectrometric–proteomics study that the topoisomerase IIα monomer contains at least 5 free cysteines (amino acids 170, 216, 300, 392, and 405) [10].
The role of glutathione in cadmium ion detoxification: Coordination modes and binding properties - A density functional study
2009, Journal of Inorganic BiochemistryMetal binding to ligands: Cadmium complexes with glutathione revisited
2007, Analytical BiochemistryCitation Excerpt :More precise estimation remains difficult due to the poorly controlled possible adsorption of cadmium onto the vessel walls (Fig. 3A and Supplemental Fig. S2). Nevertheless, this result is consistent with calculations based on previously published absolute constants (e.g., those in Refs. [9,11]) and with the conditional constant of 10−5 M reported in one previous study [13] under slightly more alkaline pH conditions (pH 7.3). It is more difficult to compare our results with those of a previous study [10] (selected by the NIST database) because this would imply correction for the very high ionic strength used in that previous study (3 M).