Cell
Volume 67, Issue 4, 15 November 1991, Pages 723-730
Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation
References (38)
- et al.
Properties of β-adrenergic receptors of cultured mammalian cells
J. Biol. Chem.
(1985) - et al.
Activation of the inhibitory GTP-binding protein of adenylate cyclase, Gi, by β-adrenergic receptors in reconstituted phospholipid vesicles
J. Biol. Chem.
(1984) - et al.
Preparation of homogeneous cyclic AMP-dependent protein kinase(s) and its subunits from rabbit skeletal muscle
Meth. Enzymol.
(1974) - et al.
Phosphorylation of the mammalian β-adrenergic receptor by cyclic AMP-dependent protein kinase
Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein
J. Biol. Chem.
(1985) - et al.
Synthetic segments of the mammalian βAR preferentially recognized by cAMP-dependent protein kinase and protein kinase C
Biochem. Biophys. Res. Commun.
(1987) - et al.
Two distinct pathways for cAMP-mediated down-regulation of the β-adrenergic receptor
Phosphorylation of the receptor and regulation of its mRNA level
J. Biol. Chem.
(1989) - et al.
Specificity of the functional interactions of the β-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles
J. Biol. Chem.
(1985) - et al.
Specific activation of Gs by synthetic peptides corresponding to an intracellular loop of the β-adrenergic receptor
FEBS Lett.
(1991) - et al.
Optimal spatial requirements for the location of basic residues in peptide substrates for the cyclic AMP-dependent protein kinase
J. Biol. Chem.
(1980) - et al.
Phosphorylation sites on two domains of the β2-adrenergic receptor are involved in distinct pathways of receptor desensitization
J. Biol. Chem.
(1989)
Mastoparan, a peptide from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins)
J. Biol. Chem.
(1988)
Guanine nucleotide inhibition of cyc-S49 mouse lymphoma cell membrane adenylyl cyclase
J. Biol. Chem.
(1982)
The influence of basic residues on the substrate specificity of protein kinase C
J. Biol. Chem.
(1987)
N-(2-aminoethyl)5-isoquinolinesulfonamide, a newly synthesized protein kinase inhibitor functions as a ligand in affinity chromatography; purification of calcium-activated, phospholipid-dependent and other protein kinases
J. Biol. Chem.
(1985)
A new GTP-binding protein in brain tissue serving as the specific substrate of islet-activating protein, pertussis toxin
FEBS Lett.
(1987)
Purification and identification of two pertussis-toxin-sensitive GTP-binding proteins of bovine spleen
Biochem. Biophys. Res. Commun.
(1989)
Isolation of three types of Gi from bovine spleen
Biochem. Biophys. Res. Commun.
(1990)
Distinctive regulation of the functional linkage between the human cation-independent mannose 6-phosphate receptor and GTP-binding proteins by insulin-like growth factor II and mannose 6-phosphate
J. Biol. Chem.
(1990)
Possible direct linkage of insulin-like growth factor II receptor with guanine nucleotide-binding proteins
J. Biol. Chem.
(1989)
Cited by (256)
Biased signaling of G protein coupled receptors (GPCRs): Molecular determinants of GPCR/transducer selectivity and therapeutic potential
2019, Pharmacology and TherapeuticsCitation Excerpt :This peptide activates Gs at nanomolar concentrations in vitro and weakly activates Gi. Whereas, PKA-mediated phosphorylation at the conserved RRXS site dramatically reduced Gs activation, but enhanced Gi activation (Okamoto et al., 1991). Phosphorylation-dependent switch of coupling to non-cognate G protein pathways has also been reported for many GPCRs including adrenergic β1 and β2 (Martin, Whalen, Zamah, Pierce, & Lefkowitz, 2004; Zamah, Delahunty, Luttrell, & Lefkowitz, 2002), prostanoid IP receptor (Miggin & Kinsella, 2002), μOR and δOR (Kramer, Andria, Esposito, & Simon, 2000; Zhang, Zhao, Qiu, Loh, & Law, 2009), CB1R (Paquette et al., 2007), and glutamate mGluR5 (Dupont, Loomekandja Lokenye, & Challiss, 2011).
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Copyright © 1991 Published by Elsevier Inc.