ArticleRole of dopaminergic mechanisms in the stimulatory effects of MK-801 injected into the ventral tegmental area and the nucleus accumbens
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2020, Behavioural Brain ResearchCitation Excerpt :Consistently, pharmacological activation of NMDA and AMPA glutamate receptors in the VTA increases mesolimbic DA release [17,18] and exploratory motor behavior [19] in rodents. However, other studies have reported increased DA release and burst firing of DA neurons [20,21], as well as enhanced locomotor activity [22,23] following blockade of VTA NMDA or AMPA receptors, suggesting an opposite modulatory role of glutamate on DA neuronal activity. Prior reports from our group have also shown that blockade of VTA NMDA receptors enhances the rewarding effect obtained through intracranial self-stimulation (ICSS), a phenomenon also termed brain stimulation reward [24–26], whereas the opposite effect is observed following blockade of VTA AMPA receptors [25].
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2018, Schizophrenia ResearchCitation Excerpt :Positive modulation of hippocampal GABAB receptors may normalize the firing of hippocampal interneurons that are dis-excited by NMDAR blockade (Grunze et al., 1996), and thus normalize hippocampal gamma activity. However, other than the hippocampus, it is likely that a systemic GABAB receptor PAM normalize PPI and other psychosis-relevant behaviors by acting on GABAB receptors in different parts of the brain, including the pedunculopontine nucleus (PPN; Arai et al., 2008), prefrontal cortex (Fejgin et al., 2009), thalamus (Zhang et al., 2012), and ventral tegmental area (Erhardt et al., 2002) and NAc (Hunt et al., 2010; Narayan et al., 1996). How aberrant hippocampal gamma activity affects PPI and behavioral hyperactivity is not clearly known.
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