ArticleAversive effects of the synthetic cannabinoid CP 55,940 in rats
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2020, Neuroscience Lettersβ-lactams modulate astroglial glutamate transporters and attenuate dependence to CP 55,940, a CB1 receptor agonist, in rat model
2019, Behavioural Brain ResearchCitation Excerpt :Previous reports on cannabinoids demonstrated that any slight modification in the CPP procedure might produce a dramatic shift in CPP outcomes [for review, see Ref. [63]. For example, aversive effects were reported when CP was administered daily for four days in conditioning training [51], which could account for the failure to observe a positive CPP effect. Moreover, the narrow interval between cannabinoids injections can produce a similar dysphoric effect on the brain’s reward threshold, which may mask the rewarding effect, as proposed in previous report [53].
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2018, European Journal of Medicinal ChemistryAntagonism of the kappa opioid receptor attenuates THC-induced place aversions in adult male Sprague-Dawley rats
2017, Pharmacology Biochemistry and BehaviorCitation Excerpt :Subjects assigned to the norBNI group were injected subcutaneously (SC) with norBNI (15 mg/kg) 24 h prior to place conditioning; subjects assigned to the Vehicle group were injected SC with the norBNI vehicle. Given that THC typically produces a conditioned place aversion in rats (Mallet and Beninger, 1998; McGregor et al., 1996; Parker and Gillies, 1995; Sañudo-Peña et al., 1997), each animal was given THC on its own initially preferred side (for similar procedures with drugs that typically induce place aversions, see Cunningham et al., 2003; Davis et al., 2007; Schenk et al., 1986). Specifically, 24 h after norBNI/vehicle administration (see above), animals in each pretreatment group were randomly assigned to receive an intraperitoneal (IP) injection of THC (0, 0.56, 1 or 3.2 mg/kg).
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