Marihuana smoking increases plasma cocaine levels and subjective reports of euphoria in male volunteers
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Smoked cannabis reduces peak cocaine plasma levels and subjective effects in a controlled drug administration study of polysubstance use in men
2023, Drug and Alcohol DependenceCitation Excerpt :Understanding the nature of cannabis-cocaine interactions will provide clinically relevant information that identifies abuse liability and health risks while laying the groundwork for developing treatment strategies. Initial laboratory studies indicate that acute cannabis exposure may enhance behavioral and physiological responses to insufflating or intravenous cocaine (Foltin and Fischman, 1989; Foltin et al., 1995; Foltin et al., 1987; Foltin et al., 1993; Lukas et al., 1994). However, these early studies did not consistently use a cannabis-only condition in the study design to assess potential additive effects of the drugs.
Cannabis-drug interactions: Implications for medicinal cannabis use
2023, Medicinal Usage of Cannabis and CannabinoidsEffects of cocaine and/or heroin use on resting cardiovascular function
2021, International Journal of Cardiology: Cardiovascular Risk and PreventionCitation Excerpt :Moreover, these drugs can modulate effects of cocaine and/or heroin. For example, by attenuating vasoconstrictive effect of cocaine, cannabis-induced vasodilation enhances absorption of cocaine and its toxic effects [37]. Such findings suggest clinicians should consider demographics, BMI, and polysubstance use when examining cardiovascular effects of individual drugs.
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2018, Drug and Alcohol DependenceRelation of Cannabis Use and Atrial Fibrillation Among Patients Hospitalized for Heart Failure
2018, American Journal of CardiologyCitation Excerpt :Our study utilized the largest available inpatient data in the United States to examine this association and adjusted for all known risk factors of AF. In addition, cannabis users are most likely abusers of other recreational drugs such as opioid, amphetamine, psychostimulants, cocaine, sedatives, antidepressants, and hallucinogens known to have adverse effects on the cardiovascular system.39–41 It is possible that polysubstance use accounts for the incidences of AF seen in these case reports.