Relationship of the behavioral effects of aprophen, atropine and scopolamine to antagonism of the behavioral effects of physostigmine☆
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2009, Neurotoxicology and TeratologyCitation Excerpt :Performance under the control of operant schedules has been shown to be sensitive to disruption by a variety of pharmacological agents, including cholinergic compounds e.g., [15] and [16]. We have shown previously that, in rats, physostigmine, a reversible cholinesterase inhibitor, decreases responding maintained by fixed-ratio schedules [17] and variable-interval schedules [19]. Furthermore, with repeated administration, tolerance develops to the response deficit produced by physostigmine [18].
Behavioral evaluation of rats following low-level inhalation exposure to sarin
2009, Pharmacology Biochemistry and BehaviorDifferential effects of anticholinergic drugs on paired discrimination performance
1996, Pharmacology Biochemistry and BehaviorBehavioral comparison of the oximes TMB-4, 2-PAM, and HI-6 in rats using operant conditioning
1996, Pharmacology Biochemistry and Behavior
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In conducting the research described in this report, the investigators adhere to the “Guide for the Care and Use of Laboratory Animals,” as promulgated by the Committee on Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources, National Research Council. The views of the authors do not purport to reflect the position of the Department of the Army or the Department of Defense (para 4-3, AR 360-5).
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Present address: Psychobiology Laboratory, NIDA Addiction Research Center, Baltimore, MD 21224.