Comparative behavioral profile of cocaine and norcocaine in rats and monkeys☆
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2015, Behavioural Brain ResearchCitation Excerpt :Nevertheless, evidence suggests that buspirone can attenuate the delayed aversive effects of cocaine resulting in CPA [180]. Several studies have shown drug-seeking and self-administration of cocaine in rodents [30], dogs [599], and monkeys [56,316,600] under different schedules of reinforcement. An inverted U-shaped dose–response function was established for infusion of cocaine under fixed-ratio schedules [53,689].
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2011, SteroidsCitation Excerpt :These results are concordant with earlier studies in which testosterone has been shown to attenuate amphetamine induced locomotor activity and stereotyped behavior [30–32], and our own studies where nandrolone has been shown to blunt the stereotyped behavior and locomotor activity induced by amphetamine, MDMA and cocaine [8,33,7]. Correlation with microdialysis results is to be expected, because stimulant-induced hyperlocomotion is predominantly mediated by increased of DA in the NAc [34–36]. This is in line with previous studies where it has been shown that pre-treatment with nandrolone decanoate modulates, and induces, long lasting changes in the behavioral responses in rats.
The effects of cocaine on light-induced activity
2011, Brain Research BulletinCitation Excerpt :In parallel to that, also the behavioural activation becomes significantly bigger than during LIA. Although both, cocaine and on–off light stimulation, may serve as reinforcers for which animals would be willing to work [2,3,18,33,42], considering the relationship between cocaine and LIA, the present study provides some important behavioural results to differentiate between the two. In comparison to LIA, the increases in locomotion and rearing elicited as a function of cocaine dosage in the no light condition were much greater in magnitude.
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2007, Progress in Neurobiology
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Supported by NIDA grant DA-00810 awarded to Dr. Marvin Wilson and by the Research Institute of Pharmaceutical Sciences. Portions of this paper were presented at the 1979 FASEB meeting, Dallas, Texas.