PaperInhibition of platelet aggregation and thromboxane synthesis after intake of small amount of icosapentaenoic acid
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2021, Evidence-Based Nutrition and Clinical Evidence of Bioactive Foods in Human Health and DiseaseOxygenation of polyunsaturated fatty acids and oxidative stress within blood platelets
2018, Biochimica et Biophysica Acta - Molecular and Cell Biology of LipidsCitation Excerpt :On the opposite of increased platelet activation, moderate concentrations of long-chain omega-3 PUFA (EPA and DHA) may lower such activation, although these PUFA are usually considered as highly sensitive to peroxidation [74]. Indeed, low intake of EPA by elderly people, who show elevated oxidative stress, including in platelets, significantly decreased platelet aggregation and thromboxane production [75], likely through platelet vitamin E protection, resulting in its elevation [76]. This could be reproduced with normal platelets in vitro [77].
Role of Fish Oil in Post-Cardiotomy Bleeding: A Summary of the Basic Science and Clinical Trials
2018, Annals of Thoracic SurgeryOmega-3 polyunsaturated fatty acids and oxygenated metabolism in atherothrombosis
2015, Biochimica et Biophysica Acta - Molecular and Cell Biology of LipidsCitation Excerpt :After supplementation with EPA, von Schacky and Weber [7] found a decreased platelet reactivity and an increased docosapentaenoic acid (DPA; 22:5ω3), an intermediate between EPA and DHA (Fig. 1). In addition, low intake of EPA may reduce platelet aggregation, without changing the fatty acid platelet composition [64,65]. In the same way, following supplementation with DHA [7], platelet function was reduced and a retroconversion of DHA into DPA and EPA was evidenced.
Long-chain omega 3 fatty acids: Molecular bases of potential antioxidant actions
2014, Prostaglandins Leukotrienes and Essential Fatty AcidsCitation Excerpt :Of note, this antioxidant effect was also observed in pregnancy [20]. Finally, the Lagarde and Calzada group proposed a threshold below which PUFA supplementation results in antioxidant actions and above which pro-oxidant activities take place [24–26]. Very recently, EPA and DHA supplementation was shown to lower plasma lipoperoxide concentrations in mild cognitive impairment patients [27].
Influence of omega-3 polyunsaturated fatty acid-supplementation on platelet aggregation in humans: A meta-analysis of randomized controlled trials
2013, AtherosclerosisCitation Excerpt :However, our meta-analysis showed that decreases were usually shorter term (less than 8 weeks) and/or when using lower dosage of n-3 PUFAs. Small doses of n-3 PUFAs have documented inhibitory effects on platelet function while causing no changes in plasma lipids or lipoproteins [26]. The data obtained from a recent study strongly indicate that not only total concentrations of n-3 PUFAs in the platelet compartment but also distribution of EPA or DHA in selected phospholipid pools may be responsible for the different platelet responses to collagen [25].