Mitochondrial dysfunction is an early event in ochratoxin a but not oosporein toxicity to rat renal proximal tubules
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Ochratoxin A: its impact on poultry gut health and microbiota, an overview
2021, Poultry ScienceCitation Excerpt :OTA exerts its effect on the gut via reduction of nutrient absorption, disruption of intestinal permeability, and modulation of the immune system. The first expression of OTA toxicity is immunosuppression, which may become clinically apparent before nephropathy is manifested (Aleo et al., 1991). The gut is the first defense barrier against various types of contamination in food (Grenier and Oswald, 2011); therefore, compared with other tissues, it is exposed to mycotoxins at higher concentrations upon ingestion of contaminated food (Marie-Caroline et al., 2016).
Effects of Mycotoxins on Neuropsychiatric Symptoms and Immune Processes
2018, Clinical TherapeuticsToxicological effects of regulated mycotoxins and persistent organochloride pesticides: In vitro cytotoxic assessment of single and defined mixtures on MA-10 murine Leydig cell line
2018, Toxicology in VitroCitation Excerpt :OTA cytotoxicity reported here is similar to that for OTA in other cell lines, including Caco-2 cells, mouse RAW264.7 macrophages and Madin-Darby Bovine Kidney (MDBK) cells (Clarke et al., 2014), Vero cells (Bouslimi et al., 2008; Golli-Bennour et al., 2010) and porcine PK15 cells (Klarić et al., 2008, 2012). The cytotoxic effect of OTA, particularly at high concentrations can be attributed to the fact that OTA has the ability to inhibit protein synthesis (Creppy et al., 1983), impair mitochondrial phosphorylation (Wei et al., 1985; Aleo et al., 1991); disrupt the nuclear factor-erythroid 2 p45-related factor 2 (Nrf2)-dependent pathway resulting to lipid peroxidation, proteolytic stress and oxidative DNA damage (Cavin et al., 2007, 2009; Limonciel and Jennings, 2014), induce cell apoptosis (Schwerdt et al., 1999; Schilter et al., 2005; Rached et al., 2006; Malir et al., 2016), and dysregulate mitosis by interfering with the activity of histone acetyltransferases (Adler et al., 2009; Czakai et al., 2011; Mally, 2012). In this study, AFB1 was not very cytotoxic to MA-10 cells, with only a slight increase in toxicity seen above 8 μM.