General paperTherapeutic brain concentration of the NMDA receptor antagonist amantadine
References (45)
- et al.
Amantadine induced lipidosis. A cytological and physicochemical study
Toxicology
(1987) - et al.
Accumulation of amantadine by isolated chromaffin granules
Biochem. Pharmac.
(1981) - et al.
Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study
Eur. J. Pharmac. Molec. Pharmac. Sect.
(1991) - et al.
Affinity of 1-aminoadamantanes for the σ binding site in post-mortem human frontal cortex
Neurosci. Lett.
(1993) - et al.
Organspecific qualitative changes in the phospholipid composition of rats after chronic administration of the antidepressant drug desipramine
Biochem. Pharmac.
(1988) - et al.
Controlled trial of amantadine hydrochloride in Parkinson's disease
Lancet
(1970) - et al.
Patch clamp studies on the kinetic and selectivity of JV-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)
Neuropharmacology
(1993) - et al.
Influenza virus M2 protein has ion channel activity
Cell
(1992) - et al.
The intracellular distribution and antiviral activity of amantadine
Virology
(1981) Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzo-diazepines
Trends Pharmac. Sci.
(1993)
Memantine-induced dopamine release in the prefrontal cortex and striatum of the rat — a pharmacokinetic microdialysis study
Eur. J. Pharmac.
The anti-parkinsonian drug amantadine inhibits the N-methyl-Daspartic acid-evoked release of acetylcholine from rat neostriatum in a non-competitive way
Eur. J. Pharmac.
NMDA receptor-mediated glutamate toxicity of cultured cerebellar, cortical and mesencephalic neurons: neuroprotective properties of amantadine and memantine
Brain Res.
Clinical pharmacokinetics of amantadine hydrochloride
Clin. Pharmacokinetics
Absorption, distribution and excretion of amantadine hydrochloride
J. Pharmac. Exp. Ther.
Amantadine sulphate in treating Parkinson's disease: clinical effects, psychometric tests and serum concentrations
J. Neural.
Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity
J. Neurosci.
Are NMDA antagonistic properties relevant for antiparkinsonian-like activity in rats?—Case of amantadine and memantine
J. Neural Transm. Park. Dis. Dement. Sect.
Lysosomotropic agents
Biochem. Pharmac.
Effects of exogenous amines on mammalian cells, with particular reference to membrane flow
Biochem. J.
A controlled trial of amantadine in drug-induced extrapyramidal disorders
Arch. Gen. Psychiatry
Acute toxic psychosis from suicidal over-dosage of amantadine
Arch. Neural.
Cited by (109)
Hybridization of amantadine with gardenamide A enhances NMDA antagonism and in vivo anti-PD effects
2023, Bioorganic ChemistryOpen and rearranged norbornane derived polycyclic cage molecules as potential neuroprotective agents through attenuation of MPP<sup>+</sup>- and calcium overload-induced excitotoxicity in neuroblastoma SH-SY5Y cells
2020, European Journal of Medicinal ChemistryCitation Excerpt :To further validate the docking protocol, four known NMDA receptor antagonists binding at the same site as MK-801, were also docked. The molecules included phencyclidine [50], R-ketamine [50], memantine [51] and amantadine [52]. The results are summarized in Table 2 and illustrates a definite trend between binding affinity and experimental Ki value.
Effects of amantadine on corneal endothelium
2019, Experimental Eye ResearchAmantadine enhances nigrostriatal and mesolimbic dopamine function in the rat brain in relation to motor and exploratory activity
2019, Pharmacology Biochemistry and BehaviorHallmarks of Treatment Aspects: Parkinson's Disease Throughout Centuries Including L-Dopa
2017, International Review of NeurobiologyCitation Excerpt :In 1969, Coyle and Snyder suggested that the mechanism of the therapeutic action of the anticholinergic drugs in PD is related to their ability to inhibit the neuronal reuptake of dopamine in striatal neurons, thus liberating more dopamine on striatal receptors (Coyle & Snyder, 1969). Amantadine hydrochloride is a noncompetitive antagonist of N-methyl-d-aspartate receptor with rapid blocking and unblocking kinetics (Kornhuber et al., 1995). Amantadine was originally introduced in the 1960s as an antiviral agent effective against several strains of the influenza virus (Davies et al., 1964).
Stereoselective synthesis and pharmacological evaluation of [4.3.3]propellan-8-amines as analogs of adamantanamines
2015, Bioorganic and Medicinal Chemistry