Dopamine D2 receptors and dopamine metabolism: Relationship between biochemical and behavioural effects of substituted benzamide drugs
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Pharmacology profile of F17464, a dopamine D<inf>3</inf> receptor preferential antagonist
2021, European Journal of PharmacologyCitation Excerpt :F17464 pre-treatment time in this case was chosen in consideration of the high 5-HT1a receptor affinity of both F17464 and the tracer radioligand [3H]WAY100635 (Parkel and Rinken, 2006). Antipsychotics can modify dopamine turnover in the rodent central nervous system (Cartmell et al., 2000; Magnusson et al., 1986) and atypical antipsychotics can increase dopamine release in medial prefrontal cortex (Ichikawa et al., 2001; Tanda et al., 2015). F17464 (0.04, 0.16, 0.63, and 2.5 mg/kg) or saline was administered i.p. To NMRI mice (8/group) 60 min before sacrifice by microwaves (4.2 kW, 0.9–1.1 s, Sacron8000™, SAIREM, Vaulx-en-Yelin, FR) (Wasek et al., 2018).
The Influence of Metoclopramide on Trigeminovascular Nociception: Possible Anti-migraine Mechanism of Action
2020, NeuroscienceCitation Excerpt :Moreover, haloperidol and a selective D2-like receptor antagonist eticlopride were able to amplify the phasic dopamine signalling via a direct inhibitory action on dopamine uptake (Benoit-Marand et al., 2011). Metoclopramide (5–100 mg/kg, intraperitoneally) (Miller, 1976) and other D2 receptor antagonists (including haloperidol and chlorpromazine) (Magnusson et al., 1986) significantly enhanced dopamine striatal turnover in rodents. Likewise, blockade of presynaptic D2 autoreceptors on dopaminergic projections from the A11 nucleus, which provide the main source of dopamine in the TCC (Charbit et al., 2009a), would enhance extracellular dopamine level and, therefore, the tonic inhibitory dopamine action mediated by postsynaptic D2 receptors on the second-order trigeminal neurons (Charbit et al., 2009a,b; Lapirot et al., 2011).
Effects of risperidone, quetiapine and ziprasidone on ethanol withdrawal syndrome in rats
2011, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Evidence also supports the hypothesis that pyschostimulant-induced stereotypy is mediated through postsynaptic dopamine receptors (Feldman et al., 1997). Furthermore, it has been shown that dopamine D2 receptor antagonists inhibit stereotyped behaviors in rats (Magnusson et al., 1986). Thus, attenuation of ethanol withdrawal-induced stereotyped behaviors by risperidone and quetiapine, which are both dopamine D2 receptor antagonists, is not surprising.
The relationship between baseline prepulse inhibition levels and ethanol withdrawal severity in rats
2010, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :These observations may be related to the involvement of the similar receptor systems in mediating baseline PPI and EWS-induced stereotyped behaviors and wet-dog shakes. Stimulation of dopamine D1 and D2 receptors induces stereotyped behaviors (Dall'Olio et al., 1988), while D2 receptor antagonists can inhibit stereotyped behaviors in rats (Magnusson et al., 1986). Stimulation of the serotonergic system has been implicated in increased wet-dog shakes because blockade of serotonin 5-HT2 receptors inhibited wet-dog shakes in rats (Takao et al., 1995).
Effects of olanzapine on ethanol withdrawal syndrome in rats
2008, European Journal of PharmacologyCan antipsychotic drugs be classified by their effects on a particular group of dopamine neurons in the brain?
2002, European Journal of Pharmacology