Elsevier

Neuropharmacology

Volume 10, Issue 4, July 1971, Pages 459-469
Neuropharmacology

Evaluation of a rapid technique for detecting minor tranquilizers

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Abstract

A technique, based on the inhibition by foot-shocks of a simple ongoing behaviour in mice (ambulation), is suggested for the preliminary screening of the minor tranquilizers. The effect of a large number of psychotropic drugs was studied: they include minor tranquilizers, hypnotics, anticonvulsants, antihistamines, neuroleptics, antidepressants, antiparkinsonism agents, stimulants, analgesics and others. The efficiency, specificity, reliability, simplicity and disadvantages of the method are discussed.

References (17)

  • J.R. Boissier et al.

    A new method for the rapid screening of minor tranquilizers in mice

    Eur. J. Pharmac.

    (1968)
  • C. Aron

    D'un test pharmacologique utilisable pour la sélection de tranquillisants

    Thèse de Médecine

    (1970)
  • H. Barry et al.

    Effects of drugs on approach-avoidance conflict tested repeatedly by means of a “telescope alley”

    J. comp. physiol. Psychol.

    (1962)
  • J.R. Boissier et al.

    Action de la caféine sur la motilité spontanée de la souris

    Archs int. Pharmacodyn. Thér.

    (1965)
  • J.R. Boissier et al.

    Evaluation of experimental technique in the psychopharmacology of emotion

    Ann. N.Y. Acad. Sci.

    (1969)
  • L. Cook et al.

    Effects of drugs on behavior

    A. Rev. Pharmac.

    (1963)
  • P.B. Dews

    The measurement of the influence of drugs on voluntary activity in mice

    Br. J. Pharmac. Chemother.

    (1953)
  • C. Giurgea

    Pharmacological criteria for the classification of tranquilizers

There are more references available in the full text version of this article.

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