Elsevier

Life Sciences

Volume 54, Issue 20, 1994, Pages 1483-1489
Life Sciences

(-)deprenyl increases activities of Superoxide Dismutase (SOD) in striatum of dog brain

https://doi.org/10.1016/0024-3205(94)90015-9Get rights and content

Abstract

Seven beagle dogs were administered sucrose (control animals) or different doses of (-)deprenyl orally by means of capsules for 3 weeks. Activities of Cu ZnSOD and MnSOD were determined in striatum and hippocampus in these animals. There was a significant dose-dependent increase in activities of total as well as in both types of SOD enzymes in striatum but not in hippocampus. The results suggest that this monoamine oxidase B inhibitor can increase antioxidant enzyme activities in striatum but not in hippocampus in the dog, thus showing brain region selectivity. These results are in accordance with previously published observations in rats.

References (15)

  • N.W. Milgram et al.

    Life Sci.

    (1990)
  • M-C. Carrillo et al.

    Life Sci.

    (1991)
  • M-C. Carrillo et al.

    Exp. Neurol.

    (1992)
  • M-C. Carrillo et al.

    Life Sci.

    (1992)
  • M-C. Carrillo et al.

    Biochem. Pharmacol.

    (1992)
  • J. Knoll et al.

    Arch. Int. Pharmacodyn. Ther.

    (1965)
  • W. Birkmayer et al.

    J. Neur. Transm.

    (1985)
There are more references available in the full text version of this article.

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