Elsevier

Life Sciences

Volume 47, Issue 18, 1990, Pages 1683-1691
Life Sciences

Effect of prolonged 5-hydroxytryptamine uptake inhibition by paroxetine on cortical β1 and β2-adrenoceptors in rat brain

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Abstract

The effects of prolonged (21 day) oral administration of the antidepressants paroxetine (0.9 to 8.9 mg/kg/day) and amitriptyline (2.7 to 27 mg/kg/day), on rat brain cortical β1- and β2-adrenoceptor numbers and affinities were investigated using [3H]-CGP 12177. Although amitriptyline, 27 mg/kg, caused a significant (p < 0.05) 20% reduction in the number of β1-adrenoceptors, paroxetine, at doses up to 8.9 mg/kg p.o., did not influene binding of [3H]-CGP 12177 to cortical β1- or β2-adrenoceptors. This study with paroxetine provides further evidence that the down-regulation of central β1-adrenoceptors in rat brain after repeated administration is not a property of all antidepressant drugs.

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