Further evidence validating adjuvant arthritis as an experimental model of chronic pain in the rat
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2018, Prostaglandins and Other Lipid MediatorsCitation Excerpt :The supplementation of fenugreek mucilage showed mild inflammation with normal synoviocytes (mesothelial cells) tried to bring back to normal whose fluids is transudate but the indomethacin treated group showed moderate inflammation with reactive mesothelial cells. Adjuvant-induced arthritis is a well-established model in rats, has been extensively used in the study of inflammatory process [17] and validated as a model to investigate the pathogenesis of RA and to identify potential therapeutic targets [18]. The prevalence of the RA estimates in populations from different developed countries was 0.5–1% of the adult population [19].
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