Is prostacyclin the major pro-inflammatory prostanoid in joint fluid?
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Cited by (80)
Prostaglandins as potential targets for the treatment of polycystic kidney disease
2021, Prostaglandins Leukotrienes and Essential Fatty AcidsCitation Excerpt :In arthritis in particular, PGI2 has been associated with increased inflammation and worsening of disease [141]. Synovial fluid from rheumatoid arthritis patients has higher PGI2 [142], and IP knockout mice exhibit reduced arthritic scores in collagen-induced and IgG-mediated autoantibody-induced arthritis [143,144], illustrating a potentially detrimental role of PGI2 in the pathogenesis of this disorder. Similar findings have been reported in other studies using IP knockout mice [145–147], and there is also a body of older literature which suggests that IP receptor activation plays a role in mediating pain [148].
Arthritis as a disease of aging and changes in antioxidant status
2020, Aging: Oxidative Stress and Dietary AntioxidantsA systematic review on the role of eicosanoid pathways in rheumatoid arthritis
2018, Advances in Medical SciencesCitation Excerpt :PGI2 is produced by vascular endothelial cells and exerts its action through the IP receptor, mainly coupled to the Gs subunit. PGI2 is a vasodilatator, and is abundantly found in synovial fluid in rheumatoid arthritis, acting as a proinflammatory lipid mediator [56,57]. 2,3,-dinor-6 keto-PGF1α, the main metabolite of PGI2, was detected in the urinary levels of patients with RA.
Arthritis as a Disease of Aging and Changes in Antioxidant Status
2014, Aging: Oxidative Stress and Dietary AntioxidantsPlatelets can enhance vascular permeability
2012, BloodCitation Excerpt :Thromboxane A2 and prostacyclin in particular are counterbalancing mediators, the former stimulating platelet aggregation and the latter inhibiting it.58-60 Prostacyclin is present in mouse and human arthritic joints,62,63 and we have demonstrated that platelets produce prostacyclin with synoviocytes using a transcellular mechanism during arthritis.19,62,64 The balance between such mediators may thus impact platelet functions and guide the fate of the vasculature: its leakage or its preservation.