Elsevier

International Journal of Biochemistry

Volume 26, Issues 10–11, October–November 1994, Pages 1237-1247
International Journal of Biochemistry

Minireview
Biochemistry and molecular biology of drug-metabolizing sulfotransferase

https://doi.org/10.1016/0020-711X(94)90093-0Get rights and content

Abstract

Sulfation is an important conjugation reaction in the metabolism of various xenobiotics and endogenous compounds and is catalyzed by sulfotransferase (ST) present in cytosols. The cloning studies on STs have provided the basis for the understanding of the ST multigene family. STs are classified into hydroxysteroid (or alcohol), aryl (or phenol), estrogen, flavonol and polysaccharide STs and recent developments in the molecular characterization of these isoforms are reviewed. Regulation and localization of ST isoforms in various tissues are characterized at the molecular level by virtue of the specific antibodies and the corresponding cDNA probes. The recent developments are summarized. ST inhibitors are potent tools for the study on ST multiplicity and for the characterization of the enzyme structure. It also appears to be important to understand exogenous and endogenous ST inhibitors in clinical environment. The recent developments are reviewed.

References (110)

  • C.N. Falany

    Molecular enzymology of human liver cytosolic sulfotransferases

    Trends Pharmac. Sci.

    (1991)
  • K.J. Forbes-Bamforth et al.

    Identification of a new adult human liver sulfotransferase with specificity for endogenous and xenobiotic estrogens

    Biochem. biophys. Res. Commun.

    (1994)
  • C. Gibb et al.

    In vitro inhibition of phenolsulphotransferase by food and drink constituents

    Biochem. Pharmac.

    (1987)
  • R. Hobkirk

    Steroid sulfation. Current concepts

    Trends Endocrinol. Metab.

    (1993)
  • H. Homma et al.

    Immunochemical characterization of developmental changes in rat hepatic hydroxysteroid sulfotrans-ferase

    Biochim. biophys. Acta

    (1992)
  • H. Homma et al.

    Differential localization of sulfotransferase isoenzymes in rat liver

    Biochem. biophys. Res. Commun.

    (1992)
  • J.P. Horwitz et al.

    Studies on bovine adrenal estrogen sulfotransferase. III. Facile synthesis of3'-phospho- and 2-phosphoadenosine 5'-phosphosulfate

    Biochim. biophys. Acta

    (1977)
  • A.S. Khan et al.

    Genomic structure of rat liver aryl sulfotransferase IV-encoding gene

    Gene

    (1993)
  • K. Komatsu et al.

    Cloning and sequence analysis of the 5'-flananking region of the estrogen sulfotransferase gene: steroid response elements and cell-specific nuclear DNA-binding proteins

    Biochem. biophys. Res. Commun.

    (1993)
  • A-N.T. Kong et al.

    Molecular cloning of the alcohol/ hydroxysteroid form (hST,) of sulfotransferase from human liver

    Biochem. biophys. Res. Commun.

    (1992)
  • A-N.T. Kong et al.

    Molecular cloning of cDNA encoding the phenol/aryl form of sulfotransferase (mSTp1) from mouse liver

    Biochim. biophys. Acta

    (1993)
  • J.E.A. Leakey et al.

    Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. II: effects on conjugating enzymes

    Mech. Aging Dev.

    (1989)
  • T.P. Maus et al.

    Rat phenol sulfotransferase. Assay procedure, developmental changes, and glucocorticoid regulation

    Biochem. Pharmac.

    (1982)
  • K. Ogura et al.

    Cloning and sequence analysis of a rat liver cDNA encoding hydroxy-steroid sulfotransferase

    Biochem. biophys. Res. Commun.

    (1989)
  • K. Ogura et al.

    cDNA cloning of the hydroxysteroid sulfotransferase STa sharing a strong homology in amino acid sequence with the senescence marker protein SMP-2 in rat livers

    Biochem. biophys. Res. Commun.

    (1990)
  • A. Orellana et al.

    Molecular cloning and expression of a glycosaminoglycan N-acetylglucosaminyl N-deacety-lase/N-sulfotransferase from a heparin-producing cell line

    J. biol. Chem.

    (1994)
  • S. Ozawa et al.

    Expression and functional characterization of a rat sulfotransferase (ST1AI) cDNA for sulfations of phenolic substrates in COS-1 cells

    Jpn. J. Pharmac.

    (1993)
  • M. Runge-Morris et al.

    Age and gender-related gene expression of hydroxysteroid sulfotransferase-a in rat liver

    Biochem. biophys. Res. Commun.

    (1991)
  • R.D. Sekura

    Adenosine 3'-phosphate 5'-phosphosulfate

    Methods Enzymol.

    (1981)
  • S.S. Singer et al.

    Enzymatic sulfation of steroids-VII. Hepatic cortisol sulfation and glucocorticoid sulfotransferase in old and young male rats

    Exp. Grront.

    (1978)
  • S.S. Singer et al.

    Enzymatic sulfation of steroids-XX. Effects often drugs on the hepatic glucocorticoid sulfotransferase activity of rats in vitro and in vivo

    Biochem. Pharmac.

    (1984)
  • I.A. Aksoy et al.

    Human liver dehydroepiandrosterone sulfotransferase: nature and extent of individual variation

    Clin. Pharmac. Ther.

    (1993)
  • R.J. Anderson et al.

    Phenolsulphotransferase: enzyme activity and endogenous inhibitors in the human erythrocyte

    J. Lab. Clin. Med.

    (1979)
  • E.V. Barker et al.

    Dehydroepiandrosterone sulfotransferase in the developing human fetus: quantitative biochemical and immunological characterization of the hepatic, renal, and adrenal enzymes

    Endocrinology

    (1994)
  • J.D. Beckmann et al.

    Phenol sulfotransferase expression in the airways: enzymological and immunohistochemical demonstration

    Cell Tissue Res.

    (1993)
  • E.B. Borthwick et al.

    Purification and immunochemical characterization of a male-specific rat liver oestrogen sulphotransferase

    Biochem. J.

    (1993)
  • M. Cappiello et al.

    Dopamine sulphotransferase is better developed than p-nitrophenol sulphotransferase in the human fetus

    Dev. Pharmac. Ther.

    (1991)
  • J. Carroll et al.

    Regulation of hepatic sulphotransferases

    Biochem. Soc. Trans.

    (1976)
  • C.P. Chengelis

    Age- and sex-related changes in epoxide hydrolase, UDP-glucuronosyI transferase, glutathione S-transferase, and PAPS sulphotransferase in Sprague-Dawley rats

    Xenobiotica

    (1988)
  • R.H. Collins et al.

    Rat hepatic bile acid sulfotransferase: enzyme response to androgens and estrogens

    Am. J. Physiol.

    (1987)
  • K.A. Comer et al.

    Immunological characterization of dehydroepiandrosterone sulfotransferase from human liver and adrenal

    Molec. Pharmac.

    (1992)
  • K.A. Comer et al.

    Cloning and expression of human liver dehydroepiandrosterone sulphotransferase

    Biochem. J.

    (1993)
  • W.F. Demyan et al.

    Estrogen sulfotransferase of the rat liver: complementary DNA cloning and age- and sex-specific regulation of messenger RNA

    Molec. Endocrinol.

    (1992)
  • W.J. Driscoll et al.

    Isolation of two distinct 3-hydroxysteroid sulfotransferases from the guinea pig adrenal. Evidence for 3α-hydroxy versus 3β-hydroxy stereospecificity

    J. biol. Chem.

    (1993)
  • M.W. Duffel et al.

    Purification, immunochemical characterization, and immunohistochemical localization of rat hepatic aryl sulfotransferase IV

    Molec. Pharmac.

    (1991)
  • M.W. Duffel et al.

    Naphthaldehydes as reversible inhibitors of rat hepatic aryl sulfotransferase IV (tyrosine-ester sulfotransferase)

    Drug Metab. Dispos.

    (1993)
  • P.H.P. Fernando et al.

    Isolation and characterization of a novel microsomal membrane-bound phenol sulfotransferase from bovine liver

    Biochem. Molec. Biol. Int.

    (1993)
  • R.E. Galinsky et al.

    Effect of aging on drug-metabolizing enzymes important in acetaminophen elimination

    J. Pharmac. exp. Ther.

    (1986)
  • D-W. Gong et al.

    Purification of hepatic N-hydroxyarylamine sulfotransferases and their regulation by growth hormone and thyroid hormone in rats

    J. Biochem.

    (1991)
  • D-W. Gong et al.

    Hepatic triiodothyronine sulfation and its regulation by growth hormone and triiodothyronine in rats

    J. Biochem.

    (1992)
  • Cited by (59)

    • Application of reaction phenotyping to address pharmacokinetic variability in patient populations

      2023, Overcoming Obstacles in Drug Discovery and Development: Surmounting the Insurmountable-Case Studies for Critical Thinking
    • Therapeutic properties of green tea against environmental insults

      2017, Journal of Nutritional Biochemistry
      Citation Excerpt :

      One third of GTCs in mesenteric plasma are in the form of glucuronide conjugates of catechin and 3′-O-methyl catechin, suggesting that glucuronidation and methylation occur in the intestinal tract [34]. The absorbed GTC and associated metabolites are first delivered to the liver where high levels of UDP-glucuronyltransferase [35,36], sulfotransferase [37,38], and catechol-O-methyltransferase [39], among other enzymes, further metabolize GTC. After exiting the liver, GTCs and their metabolites are released into circulation system and distributed to different organs and tissues.

    • Exposure to phenanthrene and depuration: Changes on gene transcription, enzymatic activity and lipid peroxidation in gill of scallops Nodipecten nodosus

      2016, Aquatic Toxicology
      Citation Excerpt :

      This GST isoform is also suggested to be involved in the antioxidant defense system (Medeiros et al., 2008a; Rola et al., 2012), that can be important during PAH exposures. Cytosolic SULT belong to a superfamily of multifunctional phase II enzymes that catalyze sulfate conjugation in the metabolism of xenobiotics and endogenous compounds (Michio and Hiroshi, 1994). There are few studies with these proteins in bivalves. (

    • Methotrexate is a novel inducer of rat liver and intestinal sulfotransferases

      2003, Archives of Biochemistry and Biophysics
      Citation Excerpt :

      These results are in general agreement with our Western blot and enzyme activity results. ST expression is known to be primarily regulated through endogenous hormones [13,14]. This regulation is significant because it satisfies specific physiological needs.

    • cDNA cloning, expression, and functional characterization of a zebrafish SULT1 cytosolic sulfotransferase

      2003, Archives of Biochemistry and Biophysics
      Citation Excerpt :

      Sulfation of these compounds may serve to both detoxify dietary, therapeutic, and environmental xenobiotics and regulate the levels and activities of endogenous molecules such as thyroid and steroid hormones, catecholamine hormones/neurotransmitters, and bile acids [4,5]. Except during the early stage of development, cytosolic sulfotransferases in general have been shown to be constitutive enzymes with little known about the regulation of their enzymatic activities [6,7]. In recent years, however, several studies have revealed that divalent metal cations can exert dramatic inhibitory/stimulatory effects on various human cytosolic sulfotransferases [8–10].

    View all citing articles on Scopus
    View full text