Gastroenterology

Gastroenterology

Volume 109, Issue 1, July 1995, Pages 285-301
Gastroenterology

Eicosanoids and the gastrointestinal tract

https://doi.org/10.1016/0016-5085(95)90296-1Get rights and content

Abstract

Determining the role of eicosanoids in gastrointestinal physiology and pathophysiology has been an active area of investigation over the past 20 years. The landmark discovery of prostaglandin endoperoxide synthase and other enzymes involved in the production of arachidonic acid products (lipoxygenases and epoxygenases) ushered in a new era of research. The goal of this review is to distill a large body of work pertaining to studies of eicosanoids in the gastrointestinal tract. This review has been organized according both to functional (secretion and motility) and disease-related (inflammation, mucosal injury, and neoplasia) effects. The aim of this article is to present a clear summary of this area of gastroenterology so that future research can be directed in a logical and productive manner.

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    Supported by A. B. Hancock, Jr., Memorial Laboratory, Lucille P. Markey Charitable Trust, and US Public Health DK 47297-01A1 (to R.N.D.) and T32 DK07673-01A1 (to C.E.E.). Dr. DuBois is a recipient of a Veterans Affairs Research Associate Career Development Award and a Boehringer Ingelheim New Investigator Award, and Dr. DuBois is an American Gastroenterological Association Research Scholar.

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