Short communicationHemodynamic effects and histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious rats
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2019, Biochemical PharmacologyCitation Excerpt :The A3 adenosine receptor (A3AR) is a Gi protein-coupled receptor that is widely distributed, although it is most abundantly expressed in granulocytic cells including mast cells, neutrophils, and eosinophils [6–10]. In some rodents, but not in other species, the A3AR stimulates degranulation of mast cells and subsequent release of a number of biological mediators including histamine [6,11]. In prior studies, selective agonists for the A3AR have been shown to be effective at limiting injury of the heart caused by ischemia and reperfusion [5,12–20].
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