Regular paperModafinil and cortical γ-aminobutyric acid outflow. Modulation by 5-hydroxytryptamine neurotoxins
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The unfinished journey with modafinil and discovery of a novel population of modafinil-immunoreactive neurons
2018, Sleep MedicineCitation Excerpt :Indeed, unlike our cat study [17], those studies in the rat examined the effects of modafinil when the awakening effect is largely implemented. Nevertheless, modafinil would still disinhibit histaminergic and orexinergic neurons [28] by decreasing GABA outflow [19–21] in the posterior hypothalamus, thereby promoting W. This disinhibition appears, therefore, to constitute a major mechanism of action of modafinil.
Long-lasting alterations of hippocampal GABAergic neurotransmission in adult rats following perinatal Δ<sup>9</sup>-THC exposure
2017, Neurobiology of Learning and MemoryCitation Excerpt :Firstly, it is worth noting that the present release data are based on [3H]-GABA approach. Although it has been previously demonstrated that [3H]-GABA accounts for 90% of the radioactivity released under the present superfusion conditions (Tanganelli et al., 1995), we cannot rule out the possibility that this method may have some flaws. Alternatively, the most conservative explanation is that the reduction of CB1 receptor number on hippocampal GABAergic neurons in adult rats perinatally exposed to Δ9-THC might be compensated by an increase in the CB1 receptor transduction mechanism efficiency.
Modafinil reverses hypoexcitability of the motor cortex in narcoleptic patients: A TMS study
2010, Sleep MedicineCitation Excerpt :Modafinil has multiple modes of actions. It activates alpha 1- and β adrenergic receptors [4], promotes glutamate excitatory transmission in the thalamus, hippocampus, and cortex [5], reduces GABA outflow via a monoamine-mediated mechanism [6], and activates serotonergic receptors [7]; the drug also appears to have multiple effects on catecholamine systems in the brain, mainly dopamine and norepinephrine transporter inhibition [8]. However, it is still unclear what action is crucial to the wake-promoting effects in humans.
The psychostimulant modafinil facilitates water maze performance and augments synaptic potentiation in dentate gyrus
2010, NeuropharmacologyCitation Excerpt :Therefore the target of our bolus dose of modafinil was to overcome the decreased drug distribution of i.p. administration under urethane anaesthesia compared to the chronic 64 mg/kg administration of behaving rats. We also limited the i.p. dose to 150 mg/kg, avoiding the dose-dependent, secondary effects on the glutamate and GABA that occur with doses over 200 mg/kg (Tanganelli et al., 1994, 1995; Ferraro et al., 1997, 1998). Modafinil was injected (i.p.) after the initiation of the anaesthesia and 120 min before the baseline recording.