Losartan potassium, a nonpeptide antagonist of angiotensin II, chronically administered p.o. does not readily cross the blood-brain barrier
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2021, European Journal of PharmacologyCitation Excerpt :We cannot rule out that the hypotension induced by higher dose of losartan is promoting inadequate tissue perfusion and oxygen delivery. Interestingly, previous studies using 3 mg/kg of losartan have suggested that the drug does not cross the blood-brain barrier (Bui et al., 1992). On the other hand, losartan at doses of 10 and 45 mg/kg promotes antidepressant-like effect (Diniz et al., 2018).
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