Short communicationInteraction of the α-adrenoceptor agonist oxymetazoline with serotonin 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors
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Cited by (36)
Prelimbic cortex 5-HT1A and 5-HT2C receptors are involved in the hypophagic effects caused by fluoxetine in fasted rats
2015, Pharmacology Biochemistry and BehaviorCitation Excerpt :Serotonin (5-HT) is known to play an important role in both appetite and food intake regulation (Leibowitz and Shor-Posner, 1986). Also, although multiple 5-HT receptor subtypes have been identified (Schoeffter and Hoyer, 1991), recent studies point to 5-HT1A, 5-HT1B and 5-HT2C sub-type receptors as critical in mediation of food intake regulation (Heisler et al., 1998; Nonogaki et al., 1998; Steffens et al., 2010; Tecott et al., 1995). It has been suggested that impairing neurotransmission in the brain's serotoninergic system might lead to overeating (Carlson, 1989).
Medial amygdaloid nucleus 5-HT<inf>2C</inf> receptors are involved in the hypophagic effect caused by zimelidine in rats
2012, NeuropharmacologyCitation Excerpt :Serotonin has been known to play an important role in both appetite and food intake regulation (Leibowitz and Shor-Posner, 1986). Also, although multiple 5-HT receptor subtypes have been identified (Schoeffter and Hoyer, 1991), recent studies point to the 5-HT1A, 5-HT1B and 5-HT2C receptors as critical mediators of food intake regulation (Heisler et al., 1998; Nonogaki et al., 1998; Steffens et al., 2010, 2008; Tecott et al., 1995). Researchers have suggested that impairing neurotransmission in the brain's serotoninergic system might lead to overeating (Carlson, 1989).
Both α <inf>2B</inf>- and α <inf>2C</inf>-adrenoceptor subtypes are involved in the mediation of centrally induced gastroprotection in mice
2011, European Journal of PharmacologyCitation Excerpt :However, because of the lack of sufficiently selective α2B- and α2C-adrenoceptor ligands, difficulties were raised to determine whether α2B-, α2C- or both subtypes are involved in gastric mucosal protection. In addition, most ligands acting at α2-adrenoceptors can bind to either imidazoline or to other non-adrenergic receptors (like 5-HT1A) as well (Gyires et al., 2009; Link et al., 1995; Meana et al., 1996; Schoeffter and Hoyer, 1991). Our present results obtained from genetically engineered mice demonstrate for the first time that α2B- and α2C-subtypes can equally contribute to the gastroprotective effect induced by α2-adrenoceptor agonists.
In vivo potentiation of reboxetine and citalopram effect on extracellular noradrenaline in rat brain by α<inf>2</inf>-adrenoceptor antagonism
2010, European NeuropsychopharmacologyCitation Excerpt :In addition, the majority of α2-adrenoceptor antagonists used in experimental studies are not very selective for this receptor. Thus, non-adrenergic binding sites for atipamezole (Sjöholm et al., 1999), a mixed 5-HT1A/α2-adrenoceptor profile for RX821002, yohimbine, oxymetazoline, rauwolscine, BRL44408, ARC239 and idazoxan (Convents et al., 1989; Meana et al., 1996; Newman-Tancredi et al., 1998; Schoeffter and Hoyer, 1991; Winter and Rabin, 1992) and a relevant affinity of idazoxan and efaroxan for imidazoline receptors have been demonstrated (Eglen et al., 1998; Miralles et al., 1993). This non-selective α2-adrenoceptor profile displays functional relevance when modulation of NA concentrations in the central nervous system is evaluated (Fernández-Pastor and Meana, 2002).
α<inf>2</inf>-Adrenoceptor subtypes-mediated physiological, pharmacological actions
2009, Neurochemistry International