Methoctramine reveals heterogeneity of M2 muscarinic receptors in longitudinal ileal smooth muscle membranes
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Cited by (94)
Role of muscarinic receptors in the contraction of jejunal smooth muscle in the horse: An in vitro study
2017, Research in Veterinary ScienceCitation Excerpt :By contrast, a relevant role by M1 or M2 receptor subtypes in mediating the contractions induced by exogenous ACh in horse jejunum seems to be unlikely. This latter finding might seem in contrast with previous evidence of a contribution by M2 receptors to cholinergic contraction of intestinal smooth muscle (Eglen, 2001), and with the prevalence of M2 over M3 receptors found in the small intestine of several species (Giraldo et al., 1987; Michel and Whiting, 1988; Candell et al., 1990). However, the negligible role of M2 receptors in mediating the contraction induced by exogenous ACh can be explained by the fact that this muscarinic receptor subtype, by inhibiting cAMP synthesis, opposes to the relaxation of sympathetic origin (Kume and Kotlikoff, 1991; Kotlikoff et al., 1999) but is devoid of a direct contractile action on smooth muscle cells, and therefore its effect might not be evident in isolated jejunum, in absence of adrenergic stimulation.
Further evidence for the heterogeneity of functional muscarinic receptors in guinea pig gallbladder
2000, European Journal of PharmacologyMuscarinic M<inf>2</inf> receptors are not primarily involved in the contraction of guinea-pig gallbladder smooth muscle
1999, Pharmacological ResearchDistinct functional muscarinic receptors in guinea-pig gallbladder, ileum and atria
1999, Pharmacological Research