α2-Adrenoceptor modulation of nociception in rat spinal cord: location, effects and interactions with morphine
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α<inf>2</inf>-agonists and antagonists
2022, Small Animal Critical Care MedicineComparative efficacy of epidural clonidine versus epidural fentanyl for treating breakthrough pain during labor: a randomized double-blind clinical trial
2020, International Journal of Obstetric AnesthesiaActivation of a Gq-coupled membrane estrogen receptor rapidly attenuates α<inf>2</inf>-adrenoceptor-induced antinociception via an ERK I/II-dependent, non-genomic mechanism in the female rat
2014, NeuroscienceCitation Excerpt :These findings, together with our current data, would suggest that the Gq-mER-mediated rapid and reversible suppression of clonidine-mediated antinociception depends primarily on non-genomic mechanisms. The α2-adrenoceptor is widely distributed in the brain and spinal cord, including the dorsal horn (Unnerstall et al., 1984; Sullivan et al., 1987; Stone et al., 1998). Consequently, epidural or i.t. clonidine treatment has been utilized to alleviate severe neuropathic or cancer pain even in patients with limited relief by and development of tolerance to opiates (Rauck et al., 1993; Eisenach et al., 1995; Hassenbusch et al., 1999; Dobrydnjov et al., 2005).
α2 agonists and antagonists
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2013, European Journal of Pharmacology
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