Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin

doi:10.1016/0014-2999(85)90456-X

European Journal of Pharmacology

Volume 108, Issue 3, 5 February 1985, Pages 315-319

https://doi.org/10.1016/0014-2999(85)90456-X Get rights and content

Abstract

Immunohistochemical studies showed that substance P (SP) and calcitonin gene-related peptide (CGRP) immunoreactivity co-exist in capsaicin-sensitive primary sensory neurons. Varicose SP- and CGRP-immunoreactive nerve fibres with a similar distribution pattern were seen in the lower airways and heart. The functional analysis revealed that CGRP caused cardiac stimulation and had, together with SP and neurokinin A, potent hypotensive effects. Vascular permeability was increased by SP and neurokinin A, and the bronchial smooth muscle was particularly sensitive to neurokinin A. Thus, multiple peptides stored in an possible released from the same nerve endings by capsaicin may exert differential effects in various target tissues.

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Citation Excerpt :
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Short communicationCo-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin

Abstract

Life Sci.

J. Neurosci. Meth.

Mol. Cell. Endocrinol.

Detection of substance P in central nervous system by a monoclonal antibody

Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptide

Nature

Short communication
Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin