The effects of topical capsaicin on rat urinary bladder motility in vivo
References (41)
- et al.
Peptidergic substabce P nerves in the genitourinary tract
Neuroscience
(1978) Nervous control of the urinary bladder in the cat
Brain Res.
(1975)- et al.
Organization of the sacral parasympathetic reflex pathways to the urinary bladder and large intestine
J. Autonom. Nerv. Syst.
(1981) - et al.
Immunoreactive substance P in sympathetic ganglia: distribution and sensitivity toward capsaicin
Neuroscience
(1981) - et al.
Inhibitory cholinergic synapses in autonomic ganglia
T.I.P.S.
(1983) The effect of indomethacin and substance P on the guinea pig urinary bladder
Life Sci.
(1981)- et al.
An in vivo procedure for estimating spasmolytic activity in the rat by measuring smooth muscle contractions to topically applied acetylcholine
J. Pharmacol. Meth.
(1982) - et al.
Reserpine induced detrusor hyperreflexia: an in vivo model for studying smooth muscle relaxants at urinary bladder level
J. Pharmacol. Meth.
(1983) - et al.
The effect of peripherally administered GABA on spontaneous motility of rat urinary bladder in vivo
Gen. Pharmacol.
(1983) - et al.
Neurotoxic action of capsaicin on spinal substance P neurons
Brain Res.
(1980)
Somatovesical reflexes in chronic spinal cats
J. Autonom. Nerv. Syst.
Reflex changes in the urinary bladder after mechanical and thermal stimulation of the skin at various levels in cats
Neuroscience
Sensory substance P innervation of the urinary bladder: possible site of action of capsaicin in causing urine retention in rats
Neuroscience
Evidence that the contractile response of the guinea pig ileum to capsaicin is due to release of substance P
J. Physiol. (London)
Pulmonary afferent fibers of small diameter stimulated by capsaicin and hyperinflation of the lung
J. Physiol. (London)
Afferent C fibers and cardiorespiratory reflexes
Am. Rev. Respir. Dir.
Inhibition and facilitation in parasympathetic ganglia of the urinary bladder
Reflexes to sacral parasympathetic neurons concerned with micturition in the cat
J. Physiol. (London)
Reflex activation of sympathetic pathways to vesical smooth muscle and parasympathetic ganglia by electrical stimulation of vesical afferents
J. Physiol. (London)
The action of sodium dicromoglycate on “C” fibers endings in the dog lung
Br. J. Pharmacol.
Cited by (125)
Role of capsaicin-sensitive sensory nerves in protease-activated receptor-2-mediated contraction of rat urinary bladder
2007, European Journal of PharmacologyThe role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology
2004, European Journal of PharmacologySpinal neurophysiologic correlates of the analgesic actions of intravesical dimethyl sulfoxide and capsaicin in the rat
2002, Journal of PainCitation Excerpt :This effect was only marked at the spinal cord levels of L5-S1, which are those that receive pelvic nerve input.11 Desensitization of urinary bladder afferents by capsaicin has been extensively studied by Maggi and associates, who assessed the effect of the drug on the micturition reflex.2,23,26,36 The term desensitization is usually applied to the multiple capsaicin effects and is a generic label to describe a broad series of events ranging from tachyphylaxis associated with the vanilloid receptor to a neurotoxic effect and cell death.12
Principles of tachykininergic co-transmission in the peripheral and enteric nervous system
2000, Regulatory PeptidesCitation Excerpt :At that time, in collaboration with Paolo Santicioli, we were interested in defining possible new treatments for micturition disturbances and started using capsaicin as a tool to address the neurotransmitter mechanisms regulating primary afferent input from the rat urinary bladder to the spinal cord. The connection to substance P (SP) was a quite obvious step and we obtained evidence [1,2] suggesting that TKs could have a role in excitatory nonadrenergic noncholinergic (NANC) neurotransmission to the rat detrusor muscle, although formal proof supporting this conclusion (blockade of electrically induced nerve-mediated responses by appropriate antagonists) was obtained 12 years later [3]. In 1984, following the advice of Prof. Domenico Regoli from the University of Sherbrooke, Canada, we started studying the effect of the ‘novel’ TKs, neurokinin A and neurokinin B (NKA and NKB, respectively), and were soon involved in heavy work on the characterization of TK receptors.