Quantitative comparison of the analgesic and anti-inflammatory activities of aspirin, phenacetin and acetaminophen in rodents
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Cited by (97)
sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain
2017, Pharmacological ResearchCitation Excerpt :However, VPA’s higher TD50 makes its PI value higher compared to SPD in this test. The ED50 of both SPD and VPA are either better or comparable to the commercially available NSAIDs evaluated in this model (e.g. aspirin – 82–228 mg/kg, naproxen – 13 mg/kg, ibuprofen – 33 mg/kg, piroxicam – 100 mg/kg [46,47]). On the contrary SPD’s potency in the writhing test was lower than morphine [48].
Effects of chlorogenic acid on voltage-gated potassium channels of trigeminal ganglion neurons in an inflammatory environment
2016, Brain Research BulletinCitation Excerpt :The former is caused by noxious stimuli, however, the latter is elicited by normally innocuous stimuli. The major therapy for inflammatory pain is non-steroidal anti-inflammatory drugs (NSAIDs), which has long been thought to reduce PG generation primarily through inhibiting COX (Vinegar et al., 1976). Takeda et al. (Takeda et al., 2011) have proved that voltage-gated potassium channels could be a potential therapeutic target for neuropathic or inflammatory pain such as hyperalgesia/allodynia.
Spinal 5-HT<inf>5A</inf> receptors mediate 5-HT-induced antinociception in several pain models in rats
2014, Pharmacology Biochemistry and BehaviorCitation Excerpt :Rats were placed in individual acrylic observation chambers for a 60-min acclimatization period. Rats were i.p. injected with 500 μl of a 2% acetic acid solution (Vinegar et al., 1976; Rocha-González et al., 2009), in order to induce the characteristic writhings (a contraction of the abdominal muscle together with a stretching of the hind limbs). The animals were immediately returned to the observation chambers, and the number of writhes in a 5 min-period was counted during the next 60 min.
Intracisternal administration of COX inhibitors attenuates mechanical allodynia following compression of the trigeminal ganglion in rats
2009, Progress in Neuro-Psychopharmacology and Biological PsychiatryDetermination of phenacetin and salophen analgetics in solid binary mixtures with caffeine by infrared linear dichroic and Raman spectroscopy
2008, Journal of Pharmaceutical and Biomedical AnalysisAcetaminophen
2007, xPharm: The Comprehensive Pharmacology Reference