Rating the behavioral effects of amphetamine

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Abstract

A nine point rating scale with a highly standardized protocol for assessing the continuum behavioral effects of amphetamine (e.g. hyperactivity, stereotypy, dyskinetic-reactive effects) in rats is described. Dose-response curves for d- and 1-amphetamine were obtained demonstrating a 4: 1 potency ratio of d- to 1-. The capability of the rating scale to assess antagonism of d-amphetamine by pimozide suggested that this scale may be a useful quantitative measure of neuroleptic activity of drugs.

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    Present address: Pharmacology Department, Medical College of Virginia Commonwealth University, Richmond, Virginia, U.S.A.

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