Endogenous neurotensin antagonizes methamphetamine-enhanced dopaminergic activity
Reference (33)
- et al.
Bilateral modulation of [3H]neurotensin binding by unilateral intrastriatal 6-hydroxydopamine injections: evidence from a receptor autoradiographic study
Brain Res.
(1991) - et al.
Stress-induced alterations in neurotensin, somatostatin and corticotropin-releasing factor in mesotelencephalic dopamine system regions
Brain Res.
(1987) - et al.
In vivo neurochemical and behavioral effects of intracerebrally administered neurotensin andd-Trp11-neurotensin on mesolimbic and nigrostriatal dopaminergic function in the rat
Brain Res.
(1990) - et al.
Response by the neurotensin systems of the basal ganglia to cocaine treatment
Eur. J. Pharmacol.
(1989) - et al.
Increase in spontaneous motor activity following infusion of neurotensin into the ventral tegmental area
Brain Res.
(1981) - et al.
Behavioral and neurochemical effects of neurotensin microinjection into the ventral tegmental area of the rat
Neuroscience
(1983) - et al.
Neurotensin microinjection into the nucleus accumbens antagonizes dopamine-induced increase in locomotion and rearing
Neuroscience
(1984) - et al.
Reduced CSF neurotensin concentration in drug-free schizophrenic patients
Schiz. Res.
(1988) - et al.
Neurotensin: Central nervous system effects of a hypothalamic peptide
Brain Res.
(1977) - et al.
Comparative localization of neurotensin receptors on nigrostriatal and mesolimbic dopaminergic terminals
Brain Res.
(1985)
In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain
Biochem. Pharmacol.
Role of N-methyl-d-aspartate receptors in dopamine D1-, but not2-, mediated changes in striatal and accumbens neurotensin systems
Brain Res.
Facilitation of GABA release by neurotensin is associated with a reduction of dopamine release in rat nucleus accumbens
Neuroscience
Vasoactive intestinal polypeptide in canine hearts: effect of total cardiac denervation
Am. J. Physiol.
The effects of centrally administered antisera to neurotensin and related peptides upon nociception and related behaviors
Behavioral analysis of the effect of neurotensin injected into the ventral mesencephalon on the investigatory and spontaneous motor behavior in the rat
Psychopharmacology
Cited by (52)
Modeling methamphetamine use disorder and relapse in animals: Short- and long-term epigenetic, transcriptional., and biochemical consequences in the rat brain
2023, Neuroscience and Biobehavioral ReviewsSex differences in methamphetamine use disorder perused from pre-clinical and clinical studies: Potential therapeutic impacts
2022, Neuroscience and Biobehavioral ReviewsThe role of endogenous neurotensin in psychostimulant-induced disruption of prepulse inhibition and locomotion
2012, Schizophrenia ResearchCitation Excerpt :These effects do not appear to be mediated via an action of NT at the NTR1 because the effects of d-amphetamine and dizocilpine (MK801) on PPI do not differ between NTR1 knockout mice and wildtype controls (Feifel et al., 2010). In addition, administration of the small molecule NTR antagonists, while having no effect on appetitive or aversive conditioning (Grimond-Billa et al., 2008; Norman et al., 2010) or the acute locomotor effects of psychostimulants (Poncelet et al., 1994; Gully et al., 1995; Casti et al., 2004; Panayi et al., 2005), but see (Wagstaff et al., 1994; Betancur et al., 1998; Marie-Claire et al., 2008), blocks the development of behavioral sensitization (Costa et al., 2001; Casti et al., 2004; Panayi et al., 2005; Costa et al., 2007), and apomorphine-induced turning and yawning (Poncelet et al., 1994; Gully et al., 1995). Reduction of behavioral response to stimulants is a well known model for APD action.
Response of limbic neurotensin systems to methamphetamine self-administration
2012, NeuroscienceCitation Excerpt :The design of the present METH SA study was intended to help address these questions. Using the operant training described in the Experimental procedures, we confirmed other reports that systemic stimulation of NT receptors inhibit DA activation caused by stimulants such as METH (Feifel et al., 2008; Hadden et al., 2005; Wagstaff et al., 1994). The study represented in Fig. 1 was intended to test the possibility that NT agonists block METH SA because they stimulate DA release themselves and consequently substitute for METH in a SA paradigm.
Hyperactivity of the dopaminergic system in NTS1 and NTS2 null mice
2010, NeuropharmacologyThe neurotensin analog NT69L enhances medial prefrontal cortical dopamine and acetylcholine efflux: Potentiation of risperidone-, but not haloperidol-, induced dopamine efflux
2007, Brain ResearchCitation Excerpt :Based upon behavioral studies of the effects of centrally administered NT, Nemeroff (1980) hypothesized that NT exhibits endogenous antipsychotic-like effects. Consistent with this, administration of NT into the nucleus accumbens (NAC) (Ervin et al., 1981; Nemeroff et al., 1983; Kalivas et al., 1984, 1986; Skoog et al., 1986; Ford and Marsden, 1990; Jolicoeur et al., 1993; Sarhan et al., 1997), but not the ventral tegmentum (VTA) (Kalivas et al., 1982, 1983; Cador et al., 1985; Elliott and Nemeroff, 1986), has been shown to block psychostimulant-induced hyperactivity, while blockade of NT receptors with the NT1 receptor antagonist SR48692 has been shown to enhance methamphetamine-induced hyperactivity in rodents (Wagstaff et al., 1994). Central administration of NT has also blocked conditioned avoidance responding in rodents (Luttinger et al., 1982), which is thought to predict antipsychotic activity.