Short communicationEffect of substance P and protein kinase inhibitors on β-amyloid peptide-induced proliferation of cultured brain cells☆
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Culturing conditions determine neuronal and glial excitability
2010, Journal of Neuroscience MethodsCitation Excerpt :Similar analyses of glial responses in the presence and absence of neurones required the change of culturing conditions to a non-suppressive medium type and longer maturation times. The glia-enriched cultures were cultivated initially in MEM plus supplements to increase glial proliferation (Singh et al., 1994). As the proliferating glia had a higher need for nutrients the medium was changed more often; at least every 4 days.
The redox chemistry of the Alzheimer's disease amyloid β peptide
2007, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :The redox properties of Aβ indicate it could function as both an antioxidant and a pro-oxidant under specific conditions. Aβ has been observed at low concentration (nM range) to have a neuroprotective and neurotrophic effect on neonatal cell cultures [151–156]. However, the condition(s) under which Aβ ceases to act as an anti-oxidant and function as a pro-oxidant are not clearly understood, although several lines of evidence indicate the activity is dependant on the concentration of the peptide.
Emerging evidence for the neuroprotective role of α-synuclein
2006, Experimental NeurologyStaying connected: Synapses in alzheimer disease
2004, American Journal of PathologyAmyloid-β: A chameleon walking in two worlds: A review of the trophic and toxic properties of amyloid-β
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This research was supported by a grant from the Biotechnology Center, Utah State University, Logan, UT.
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The two graduate students (J.F.C. and S.Y.L.) thank the Utah State University's Gradaute Program in Molecular Biology for partial support of their tution fee.