The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) in a rat focal ischaemia model
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The neuroprotective action of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) in a rat focal ischaemia model
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2021, Bioorganic and Medicinal Chemistry LettersEffects of AMPA receptor antagonist, NBQX, and extrasynaptic GABA <inf>A</inf> agonist, THIP, on social behavior of adolescent and adult rats
2018, Physiology and BehaviorCitation Excerpt :The design for Experiment 1 was a 2 age (adolescent; adult) × 2 sex (male; female) × 6 dose (0.0, 1.0, 2.0, 4.0, 6.0, 8.0 mg/kg NBQX) factorial with 10 animals per group (N = 240). The test doses of the selective AMPA receptor antagonist, NBQX disodium salt (2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt; Tocris Bioscience; half-life approximately 30 min [7,27] were dissolved in 0.9% sterile saline and delivered intraperitoneally (i.p.) at a volume of 2 ml/kg body weight, with control animals receiving an equivalent volume of saline. The design for Experiment 2 was a 2 age (adolescent; adult) × 2 sex (male; female) × 4 dose (0.0, 1.0, 2.0, 4.0 mg/kg THIP) factorial with 8–10 animals per group (N = 217).
The effect of AMPA receptor blockade on spatial information acquisition, consolidation and expression in juvenile rats
2016, Neurobiology of Learning and MemoryCitation Excerpt :The selective and competitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAr) antagonist, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione (NBQX disodium salt; Tocris) was dissolved in distilled water to concentrations of 5 mg/ml (13.15 mmol) and 10 mg/ml (26.29 mmol) and stored frozen. This drug readily crosses the blood-brain barrier (Gill, Nordholm, & Lodge, 1992) and has an in vivo half-life of approximately 15 min (Chizh, Cumberbatch, & Headley, 1994) making it valuable to study different phases of information processing in a juvenile rat where direct intracranial injection presents technical challenges. The 5 mg/kg NBQX dose is estimated to produce over 60% inhibition of AMPA-evoked spike activity in hippocampal neurons while the 10 mg/kg dose is estimated to produce over 80% inhibition of AMPA-evoked spike activity (Chizh et al., 1994; Mathiesen, Varming, & Jensen, 1998; Nielsen et al., 1999).
Calpains and neuronal damage in the ischemic brain: The swiss knife in synaptic injury
2016, Progress in NeurobiologyBioenergetics of cerebral ischemia: A cellular perspective
2008, Neuropharmacology
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Current address: Novo Nordisk A/S, CNS Division, Novo Nordisk Park, DK-2760 Malov, Denmark.