Translocation of zinc may contribute to seizure-induced death of neurons

doi:10.1016/0006-8993(89)90199-6

Brain Research

Volume 480, Issues 1–2, 20 February 1989, Pages 317-321

https://doi.org/10.1016/0006-8993(89)90199-6 Get rights and content

Abstract

Rats were subjected to seizures induced by kainic acid, and the resulting changes in CNS zinc staining were studied with the toluene sulfonamide quinoline fluorescence method. Seizures caused a loss of zinc staining from presynaptic boutons in many limbic and cerebrocortical regions. Simultaneously, the postsynaptic neurons that were degenerating (acidophilic) in those regions as a result of the seizure developed intense fluorescence for zinc. A possible role for zinc in the death of the postsynaptic neurons is suggested.

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^☆: Supported by DHHS Grants MH-41691 and MH-42798 to C.J.F. and DA 03982 to J.F.M.

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Short communicationTranslocation of zinc may contribute to seizure-induced death of neurons☆

Abstract

Brain Research

Neuroscience

Neuroscience

Neuroscience

Brain Research

J. Neurosci. Methods.

Brain Research

Brain Research

Brain Research

Int. Rev. Cytol.

Neurosci. Lett.

Release of endogenous zinc from brain tissue during activity

Nature (Lond.)

Inorganic gravimetric and volumetric (visual titrimetric) analysis

A critical physiological role of zinc in the structure and function of biomembranes

Life Sci.

Spontaneous and evoked release of endogenous zinc in the hippocampal mossy fiber sone of the rat in situ

Brain Research

Emerging roles of zinc ions in neuronal transmission

Transition-Metal ions (copper and zinc) in the brains of epileptogenic and normal mice

Short communication
Translocation of zinc may contribute to seizure-induced death of neurons☆