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2016, PhytomedicineCitation Excerpt :In addition, the PAG, the central area that receives signals from the thalamus, hypothalamus, cortex and the spinothalamic tract, exciting the nuclei of rostroventral medulla (RVM), exerts antinociceptive effect and inhibits the responses of the spinal cord (Perl, 2011; Steeds, 2009; Zubrzycka et al., 2011). The antinociception evoked from the PAG is opioid receptor-mediated and it can be attenuated by the concurrent administration of an opioid antagonist such as naloxone (Akil et al., 1976; Jensen and Yaksh, 1986). Therefore, the CT-βCD is able to activate CNS areas, specifically those related to pain inhibition.
Antinociceptive action of diphenyl diselenide in the nociception induced by neonatal administration of monosodium glutamate in rats
2015, European Journal of PharmacologyCitation Excerpt :The results demonstrated that the MSG administration to newborn rats reduced the thermal withdrawal latency in the hot plate test, but not in the tail immersion test, and increased the response frequency of VFH stimulation. Tail-immersion is regarded as a spinal reflex, but the mechanism of response could also involve higher brain structures (Jensen and Yaksh, 1986), while the hot-plate test produces supraspinally integrated behavioral responses (Chapman et al., 1985). In addition, mechanical hypersensitivity is stimulated by traditional methods such as Von-Frey hairs.
Contributions of peripheral, spinal, and supraspinal actions to analgesia
2014, European Journal of PharmacologyInvolvement of descending serotonergic and noradrenergic pathways in CB<inf>1</inf> receptor-mediated antinociception
2012, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Descending serotonergic RVM cells and spinal serotonin (5-HT) receptors contribute to the antinociception induced by RVM or PAG stimulation (Aimone et al., 1987). Electrical stimulation of RVM or NRM induces antinociception with spinal 5-HT release and intrathecal (i.t.) injection of nonselective 5-HT antagonists block this stimulation produced analgesia (Bardin, 2011; Fields et al., 2006; Jensen and Yaksh, 1986; Oliveras et al, 1977; Rivot et al., 1982; Zorman et al., 1982). Furthermore, analgesic effects of a variety of clinically important pain killers, including opioids, tramadol and paracetamol can be reduced by neurotoxic destruction of spinal 5-HT terminals or spinal injection of some selective 5-HT receptor antagonists (Dogrul et al., 2012; Dogrul and Seyrek, 2006; Mallet et al., 2008; Tjolsen et al., 1991;Yanarates et al., 2010).
A greater role for the norepinephrine transporter than the serotonin transporter in murine nociception
2011, NeuroscienceCitation Excerpt :This is consistent with clinical data, which has demonstrated that several TCAs potentiate morphine-induced analgesia in humans (Levine et al., 1986; Gordon et al., 1993). Consistent with this modulatory role of NE and 5-HT systems both NE and 5-HT antagonists can reduce the antinociceptive effects of morphine (Jensen and Yaksh, 1986a; Wigdor and Wilcox, 1987; Arts et al., 1991). Indeed, several TCAs increase β-endorphin levels in the hypothalamus (Sacerdote et al., 1987).
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Current address: Department of Neurology, University of Copenhagen, KAS Gentofte, DK-2900 Hellerup, Denmark.