Elsevier

Brain Research

Volume 325, Issues 1–2, 28 January 1985, Pages 287-289
Brain Research

Protective effect of diazepam pretreatment on soman-induced brain lesion formation

https://doi.org/10.1016/0006-8993(85)90324-5Get rights and content

Abstract

Histopathological analyses of brains of rats receiving a single 0.9 LD50 injection of soman, a potent anticholinesterase neurotoxin, revealed massive widespread lesions in the cerebral cortex and thalamus 4 weeks post-injection. Such lesions were not evidenced in rats receiving diazepam (2.2 mg/kg, i.m.) 10 min prior to soman treatment. Thus, anticonvulsant antidotes may aid in preventing extensive or permanent brain damage in rats surviving near-lethal soman dosages.

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Research supported in part by USAMRDC Contract DAMD 17-81-C-1202.

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The authors extend their appreciation to Mr. M. G. Bauer for technical assistance.

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