Nafion-coated electrodes with high selectivity for CNS electrochemistry

doi:10.1016/0006-8993(84)90963-6

Brain Research

Volume 290, Issue 2, 9 January 1984, Pages 390-395

https://doi.org/10.1016/0006-8993(84)90963-6 Get rights and content

Abstract

A major improvement in the selectivity of small graphite electrodes used for in vivo electrochemistry is described. The electrodes are coated with Nafion, a perfluorosulfonated polymer. This coating is practically impermeable to ascorbic acid and anionic biogenic amine metabolites and only slightly responsive to neutral metabolites. Thus it becomes selective for the cationic primary neurotransmitters, dopamine, norepinephrine and 5-hydroxytryptamine. Responses of Nafion-coated and untreated electrodes in vivo are compared.

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Nafion-coated electrodes with high selectivity for CNS electrochemistry

Abstract

Brain Res. Bull.

Life Sci.

Brain Research

Neuropharmacol.

Electrochemical detection methods for monoamine measurements in vitro and in vivo

Microprocessor-controlled apparatus for in vivo electrochemical measurement

Analyt. Chem.