The effects of alcohols and diols at the nicotinic acetylcholine receptor of the neuromuscular junction
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Greater ethanol inhibition of presynaptic dopamine release in C57BL/6J than DBA/2J mice: Role of nicotinic acetylcholine receptors
2015, NeuroscienceCitation Excerpt :This suggests that the inhibitory effects of ethanol on dopamine could be either through enhanced activation (and subsequent desensitization) or blockade of nAChRs. The caveat with desensitization of β2-containing nAChRs is that ethanol has been shown to increase nAChR-mediated cation conductance in heteromeric receptors containing specific subunit combinations, including α2β2, α2β4, α4β2 and α4β4 containing receptors (Bradley et al., 1984; Cardoso et al., 1999; Zuo et al., 2001; Borghese et al., 2003). While these previous studies may suggest that ethanol mostly increases heteromeric nAChR activity, ethanol-mediated desensitization of heteromeric nAChRs is still under investigation, and may involve secondary signaling effectors not examined in the previous reports.
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