Relationship of duration of analgesia to opioid pharmacokinetic variables
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Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies
2021, Drug and Alcohol DependenceCitation Excerpt :In both studies that demonstrated analgesic efficacy, the opioid was administered at trough methadone or buprenorphine levels (Hay et al., 2008; Huhn et al., 2019); in others, however, opioid administration at trough OAT levels did not produce analgesia (Athanasos et al., 2019; Athanasos et al., 2006; Compton et al., 2000; Doverty et al., 2001). Notably, the analgesic effects of methadone and buprenorphine may be both time- and dose-dependent, and are generally shorter in duration than their withdrawal suppression effects, which may specifically affect experimental pain assessments conducted at peak OAT levels (Levine et al., 1983). This variation in analgesic effects is in part due to individual differences in elimination half-lives, which can result in distinct rates of accumulation, with potential impact on analgesia (Mercadante et al., 1996).
Do food and dose timing affect the efficacy of sildenafil? A randomized placebo-controlled study
2007, Journal of Sexual MedicineCitation Excerpt :All of these data suggest that the duration of action of sildenafil substantially exceeds its terminal elimination half‐life of approximately 4 hours [7]. This finding is not surprising, as other drug classes have durations of action that substantially exceed half‐lives [25–28]. The long duration of action of sildenafil may be related to its extensive distribution into tissues [18].
Clinical observations on controlled-release morphine in cancer pain
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1986, Brain ResearchIs the reduced efficacy of morphine in diabetic rats caused by alterations of opiate receptors or of morphine pharmacokinetics?
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This research was supported by NIH Grants AM 32634, DE 05369, DA 01949 and a KROC foundation grant.