Elsevier

Brain Research

Volume 217, Issue 1, 27 July 1981, Pages 212-215
Brain Research

Intrathecal substance P elicits a caudally-directed biting and scratching behavior in mice

https://doi.org/10.1016/0006-8993(81)90203-1Get rights and content

Abstract

Intrathecal injection of substance P in mice elicited a dose-related biting and scratching response. Systemic but not intrathecal morphine sulfate antagonized this response. We interpret these observations to define a novel nociceptive response to intrathecal substance P.

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This work was supported by USPHS Grants DA01933-02, T32 GM07397 and Grant RR05385.

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We wish to thank Ms. Cathy Cleary and Mr. Kevin Sullivan for technical assistance.

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