Control of insulin secretion by sulfonylureas, meglitinide and diazoxide in relation to their binding to the sulfonylurea receptor in pancreatic islets
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Emerging molecular technologies for light-mediated modulation of pancreatic beta-cell function
2022, Molecular MetabolismCitation Excerpt :Additionally, nateglinide is 1000-fold more selective for KATP+ channels in β-cells vs. cardiomyocytes. In albino mouse islets, 100 μM of tolbutamide, 1 μM of glipizide or 100 μM of meglitinide stimulates a rapid 8- to 9-fold increase of insulin secretion above basal values within 10 min in the presence of 10 mM glucose [44,45]. In pancreas, high voltage-gated Ca2+ channels (HVCCs) also play a significant role of in β-cell glucoregulatory insulin release, as the influx of calcium ions via HVCC initiate the Ca2+ -dependent exocytosis of insulin [46].
Lipophilicity of acidic compounds: Impact of ion pair partitioning on drug design
2011, Bioorganic and Medicinal Chemistry LettersBerberine inhibits PTP1B activity and mimics insulin action
2010, Biochemical and Biophysical Research CommunicationsCitation Excerpt :We reproduced the results with both DIO mice and db/db mice that are the early type 2 diabetes model [25] and severe diabetes model respectively. Unlike the anti-diabetes drugs sulfonylureas and meglitinides that increase insulin release [26,27], BBR did not increase insulin secretion from the pancreas nor increase the synthesis of insulin, suggesting that BBR does not change pancreas biology. These data further support that BBR plays a role through activation of the insulin signaling.
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Some results of this study were obtained during medical thesis work.