Elsevier

Biochemical Pharmacology

Volume 31, Issue 2, 15 January 1982, Pages 205-209
Biochemical Pharmacology

Hepatic extraction of bile acids in rats

https://doi.org/10.1016/0006-2952(82)90212-XGet rights and content

Abstract

The hepatic extraction ratio (Eh) of five common bile acids was determined by comparison of the area under the plasma concentration time curve (AUC) after administration into the femoral and portal veins of rats. Taurocholic acid (TCA), glycocholic acid (GCA), cholic acid (CA), deoxycholic acid (DCA) and chenodeoxycholic acid (CDCA) were studied. Using equimolar doses of the bile acids (9.3 μmoles), the effects of both conjugation and the number and position of hydroxyl groups on Eh were compared. TCA had the highest Eh (about 80 per cent) followed in order by GCA (65 per cent), CA (55 per cent) and CDCA (55 per cent), with DCA exhibiting the lowest Eh (40 per cent). This suggests that conjugation has a more important effect on hepatic extraction of bile acids than the number of hydroxyl groups.

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This study was supported by funds from Public Health Service Grant AM14513.

Present address: Faculty of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan.

Author to whom all correspondence should be sent.

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