Hepatic extraction of bile acids in rats☆
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Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification
2018, European Journal of Medicinal ChemistryCitation Excerpt :From a physiological point of view, the binding of BAs to albumin strongly influences their circulating levels, determining both the unbound fraction and the rate of hepatic clearance from portal blood [23,24]. Particularly, the hepatic extraction efficiency results to be inversely correlated to the extent of BA binding to serum albumin [24,33,34]. Although the relative rate constants should be determined, it can be speculated a less efficient biliary secretion for BA-3Gs with respect to their corresponding N-acylamidated BAs, in favour of spill over into the systemic circulation.
The Regulation of Cholesterol Conversion to Bile Acids
1996, Advances in Molecular and Cell BiologyDifferential effects of cyclosporin A on transport of bile acids by rat hepatocytes: Relationship to individual serum bile acid levels
1994, Toxicology and Applied PharmacologyBiliary excretion of chenodeoxycholyllsylrhodamine in Wistar rats: A possible role of a bile acid as a carrier for drugs
1992, Biochimica et Biophysica Acta (BBA)/Lipids and Lipid MetabolismHepatic uptake and biliary secretion of bile acids in the perfused rat liver
1992, Pharmacological Research
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This study was supported by funds from Public Health Service Grant AM14513.
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Present address: Faculty of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan.
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Author to whom all correspondence should be sent.