Elsevier

Biochemical Pharmacology

Volume 22, Issue 4, 15 February 1973, Pages 485-492
Biochemical Pharmacology

Species differences in the biliary excretion of morphine, morphine-3-glucuronide and morphine-3-ethereal sulfate in the cat and rat,☆☆

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Abstract

Biliary excretion of sulfobromophthalein (BSP) and morphine, morphine ethereal sulfate (MES) and morphine glucuronide (MG) as N-14C-methyl-labeled compounds was determined in renal-ligated rats and cats. After morphine administration the rat excreted MG and the cat MES. When administered to both species, MG and MES were excreted into bile unchanged. The rat excreted greater than 60 per cent of a morphine or MG dose into bile in 3 hr, but less than 30 per cent of a MES dose. The cat, in contrast, excreted less than 30 per cent of all three compounds. The quantitative similarity in excretion of MES between species and quantitative difference in excretion of MG between the same species suggest that MES and MG are not excreted into bile by the same pathway.

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    Citation Excerpt :

    In human, rabbit, and rat, the glucuronide metabolites are the major metabolite and the sulfate metabolite is a minor metabolite which accounts for ∼2% of the metabolites from urine (Frölich et al., 2011; Smith et al., 1973; Skarke and Lötsch, 2002). In contrast, in cat and chicken, the sulfated metabolite is a major metabolite which accounts for ∼20% of morphine and its metabolite from urine instead of the glucuronide metabolite (Fujimoto and Haarstad, 1969; Smith et al., 1973). Previous studies have demonstrated that the sulfated metabolites of hydromorphone, levorphanol, nalorphine, and naloxone have been also identified from urine and/or bile in certain species including rat, dog, cat, and human (Leinweber et al., 1981; Yeh and Woods, 1971; Zheng et al., 2002).

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This work was supported by U.S. Public Health Service Grant GM-16503.

☆☆

Preliminary results were presented at the Fifty-sixth Annual Meeting of the Federation of American Societies for Experimental Biology, Atlantic City, N.J., April 9–12, 1972.

Research Teaching Assistant, Medical College of Wisconsin.

§

Predoctoral Trainee, supported by U.S. Public Health Service Research Training Grant GM-00370.

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