Species differences in the biliary excretion of morphine, morphine-3-glucuronide and morphine-3-ethereal sulfate in the cat and rat☆,☆☆
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Cited by (21)
Sulfation of opioid drugs by human cytosolic sulfotransferases: Metabolic labeling study and enzymatic analysis
2014, European Journal of Pharmaceutical SciencesCitation Excerpt :In human, rabbit, and rat, the glucuronide metabolites are the major metabolite and the sulfate metabolite is a minor metabolite which accounts for ∼2% of the metabolites from urine (Frölich et al., 2011; Smith et al., 1973; Skarke and Lötsch, 2002). In contrast, in cat and chicken, the sulfated metabolite is a major metabolite which accounts for ∼20% of morphine and its metabolite from urine instead of the glucuronide metabolite (Fujimoto and Haarstad, 1969; Smith et al., 1973). Previous studies have demonstrated that the sulfated metabolites of hydromorphone, levorphanol, nalorphine, and naloxone have been also identified from urine and/or bile in certain species including rat, dog, cat, and human (Leinweber et al., 1981; Yeh and Woods, 1971; Zheng et al., 2002).
Role of morphine glucuronide metabolites in morphine dependence in the rat
1997, Pharmacology Biochemistry and BehaviorPurification, characterization and partial primary structure of morphine 6-dehydrogenase from rabbit liver cytosol
1997, Archives of Biochemistry and BiophysicsDemonstration of cell sidedness in hepatic transfer of morphine and morphine glucuronide in the rat
1986, Biochemical PharmacologySecretion of the organic anion harmol sulfate from liver into blood. Evidence for a carrier-mediated mechanism
1985, Biochemical PharmacologyEffects of morphine and pentobarbital on mouse and rat renal transport systems
1979, Toxicology and Applied Pharmacology
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This work was supported by U.S. Public Health Service Grant GM-16503.
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Preliminary results were presented at the Fifty-sixth Annual Meeting of the Federation of American Societies for Experimental Biology, Atlantic City, N.J., April 9–12, 1972.
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Research Teaching Assistant, Medical College of Wisconsin.
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Predoctoral Trainee, supported by U.S. Public Health Service Research Training Grant GM-00370.