Metabolism of drugs—LXII: Isolation and identification of morphine glucuronides in urine and bile of rabbits☆
References (13)
- et al.
Tetrahedron Lett.
(1968) - et al.
J. Am. pharm. Ass., Sci. ed.
(1958) - et al.
J. pharm. Sci.
(1961) J. Pharmac. exp. Ther.
(1954)- et al.
J. Pharmac. exp. Ther.
(1957) - et al.
J. Pharmac. exp. Ther.
(1941)
There are more references available in the full text version of this article.
Cited by (51)
Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT
2020, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Next, we performed UGT assays with morphine as substrate. Although morphine can be converted to two glucuronides, the major metabolite (M-3-G) and the minor one (morphine-6-glucuronide, M-6-G) [15], it was reported that little M-6-G is generated in rats and mice [22,23]. Thus, we only focused on M-3-G generation in this study.
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2019, Biochemical PharmacologyCitation Excerpt :It was noteworthy that we were unable to determine the plasma or liver concentration profile for M6G because the levels were beyond the limits of quantification. This was not surprising as M6G is a minor metabolite generated in vivo [8]. Unlike M3G (pharmacologically inactive), M6G is reported to be a pharmacologically active metabolite [9].
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A part of this study has appeared in Tetrahedron Lett. 483 (1968).
Copyright © 1969 Published by Elsevier Inc.