Differential up-regulation of microsomal and synaptic membrane μ opioid receptors

https://doi.org/10.1016/0006-291X(85)91194-5Get rights and content

Abstract

Naltrexone was administered to rats for 7 days by osmotic minipump (5 mg/kg/day) and thereupon, forebrain μ opioid receptor levels in subcellular fractions were monitored by homologous displacement of [3H]D-ala2-mePhe4-gly-ol5 enkephalin binding. Microsomes displayed increases in μ receptor concentrations that were twofold greater than those associated with synaptic plasma membrane fractions (92 vs. 51%). Levels in crude membranes rose 77%. Binding affinities were unchanged.

References (13)

  • D. Lenoir et al.

    Brain Res

    (1984)
  • R. Dingledine et al.

    Life Sci

    (1983)
  • R. Simantov et al.

    Biochim. Biophys. Acta

    (1982)
  • R. Hitzemann et al.

    Life Sci

    (1974)
  • J. Barg et al.

    Neuroscience Lett

    (1984)
  • B.L. Roth et al.

    J. Biol. Chem

    (1981)
There are more references available in the full text version of this article.

Cited by (13)

View all citing articles on Scopus
View full text