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Purinergic signalling in the reproductive system in health and disease

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Abstract

There are multiple roles for purinergic signalling in both male and female reproductive organs. ATP, released as a cotransmitter with noradrenaline from sympathetic nerves, contracts smooth muscle via P2X1 receptors in vas deferens, seminal vesicles, prostate and uterus, as well as in blood vessels. Male infertility occurs in P2X1 receptor knockout mice. Both short- and long-term trophic purinergic signalling occurs in reproductive organs. Purinergic signalling is involved in hormone secretion, penile erection, sperm motility and capacitation, and mucous production. Changes in purinoceptor expression occur in pathophysiological conditions, including pre-eclampsia, cancer and pain.

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Acknowledgements

The comments by George Gorodeski about the female reproductive system were much appreciated. The author is very grateful to Dr. Gillian E. Knight for her invaluable assistance in the preparation of this review article.

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Burnstock, G. Purinergic signalling in the reproductive system in health and disease. Purinergic Signalling 10, 157–187 (2014). https://doi.org/10.1007/s11302-013-9399-7

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