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Modulation of α-Synuclein Aggregation by Dopamine: A Review

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Abstract

Parkinson’s disease (PD) is a progressive neurodegenerative disorder that is characterized by (1) the selective loss of dopaminergic neurons in the substantia nigra and (2) the deposition of misfolded α-synuclein (α-syn) as amyloid fibrils in the intracellular Lewy bodies in various region of the brain. Current thinking suggests that an interaction between α-syn and dopamine (DA) leads to the selective death of neuronal cells and the accumulation of misfolded α-syn. However, the exact mechanism by which this occurs is not fully defined. DA oxidation could play a key role is the pathogenesis of PD by causing oxidative stress, mitochondria dysfunction and impairment of protein metabolism. Here, we review the literature on the role of DA and its oxidative intermediates in modulating the aggregation pathways of α-syn.

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Authors and Affiliations

  1. Department of Pathology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, 3010, Australia

    Su Ling Leong, Roberto Cappai, Kevin Jeffrey Barnham & Chi Le Lan Pham

  2. The Mental Health Research Institute, Parkville, VIC, 3052, Australia

    Su Ling Leong, Kevin Jeffrey Barnham & Chi Le Lan Pham

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Leong, S.L., Cappai, R., Barnham, K.J. et al. Modulation of α-Synuclein Aggregation by Dopamine: A Review. Neurochem Res 34, 1838–1846 (2009). https://doi.org/10.1007/s11064-009-9986-8

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