Abstract
The development of acute tolerance to the motor impairment and anticonvulsant effects of ethanol was examined. Acute tolerance to the motor impairment effect of ethanol was shown by a decrease in the degree of intoxication, as measured on the moving belt task, at higher blood ethanol levels ranging from 206 to 256 mg/dl. There was no evidence of acute tolerance to the anticonvulsant effect of ethanol in rats tested over the same time period. These results indicate that, like chronic tolerance, acute tolerance to ethanol develops at different rates for different effects of the drug. The fact that chronic tolerance to the anticonvulsant effect of ethanol has been well documented raises doubts about the assumption that similar physiological changes underlie acute and chronic tolerance to a drug effect, and support the idea that the relationship between acute and chronic tolerance is more complex than previously thought.
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References
Chen CS (1968) A study of alcohol-tolerance effect and an introduction of a new behavioral technique. Psychopharmacologia 63:433–440
Crowell CR, Hinson RE, Siegel S (1981) The role of conditional drug responses in tolerance to the hypothermic effects of ethanol. Psychopharmacology 73:165–167
Gallaher EJ, Parsons LM, Goldstein DB (1982) The rapid onset of tolerance to ataxic effects of ethanol in mice. Psychopharmacology 78:67–70
Gibbins RJ, Kalant H, LeBlanc AE (1968) A technique for accurate measurement of alcohol intoxication in small animals. J Pharmacol Exp Ther 159:236–242.
Grieve SJ, Griffiths PJ, Littleton JM (1979) Genetic influences on the development of ethanol tolerance and ethanol physical withdrawal in mice. Drug Alcohol Depend 4:77–86
Kalant H (1985) The 1985 Upjohn Award Lecture. Tolerance, learning and neurochemical adaptation. Can J Physiol Pharmacol 63:1485–1494
Kalant H (1988) Alcohol tolerance, dependence and withdrawal: overview of current issues. Aust Drug Alcohol Rev 7:27–34
Kalant H, Lê AD (1984) Effects of ethanol on thermoregulation. Pharmacol Ther 23:313–364
Kalant H, LeBlanc AE, Gibbins RJ (1971) Tolerance to, and dependence on, some non-opiate psychotropic drugs. Pharmacol Rev 23:135–191
Kalant H, LeBlanc AE, Gibbins RJ, Wilson A (1978) Accelerated development of tolerance during repeated cycles of ethanol exposure. Psychopharmacology 60:59–65
Lê AD, Kalant H (1990) Learning as a factor in ethanol tolerance. In: Erinoff L (ed) Neurobiology of drug abuse: learning and memory. National Institute on Drug Abuse Research Monograph 97. DHHS Pub No (ADM) 90–1677. Supt of Docs, US Govt Print Office, Washington DC, pp 193–207
Lê AD, Kiianmaa K (1988) Characteristics of ethanol tolerance in alcohol drinking (AA) and alcohol avoiding (ANA) rats. Psychopharmacology 94:479–483
Lê AD, Poulos CX, Cappell H (1979) Conditioned tolerance to the hypothermic effect of ethyl alcohol. Science 206:1109–1110
LeBlanc AE (1968) Microdetermination of alcohol in blood by gas liquid chromatography. Can J Physiol Pharmacol 46:665–667
LeBlanc AE, Gibbins RJ, Kalant H (1973) Behavioral augmentation of tolerance to ethanol in the rat. Psychopharmacologia 30:117–122
LeBlanc AE, Kalant H, Gibbins RJ (1975) Acute tolerance to ethanol in the rat. Psychopharmacologia 41:43–46
Lumeng L, Waller MB, McBride WJ, Li TK (1982) Different sensitivities to ethanol in alcohol-preferring and nonpreferring rats. Pharmacol Biochem Behav 16:125–130
Melchior CL, Tabakoff B (1981) Modification of environmental cued tolerance to ethanol in mice. J Pharmacol Exp Ther 219:175–180
Mellanby E (1919) Alcohol: its absorption into and disappearance from the blood under different conditions. Med Res Committee Special Rep 31 (Lond) 1–48
Pinel JPJ, Puttaswamaiah S (1985) Tolerance to alcohol's anticonvulsant effect is not under pavlovian control. Pharmacol Biochem Behav 23:959–964
Pinel JPJ, Colborne B, Sigalet JP, Renfrey G (1983) Learned-tolerance to the anticonvulsant effect of alcohol in rats. Pharmacol Biochem Behav (Suppl 1) 18:507–510
Pinel JPJ, Mana MJ, Renfrey G (1985) Contingent tolerance to the anticonvulsant effects of alcohol. Alcohol 2:495–499
Poulos CX, Cappell H (1991) Homeostatic theory of drug tolerance: a general model of physiological adaptation. Psychol Rev 98:390–408
Siegel S (1989) Pharmacological conditioning and drug effects. In: Goudie AJ, Emmett-Oglesby MW (eds) Psychoactive drugs: tolerance and sensitization. Humana Press, Clifton, New Jersey, pp 115–180
Smolen TN, Smolen A (1989) Blood and Brain ethanol concentrations during absorption and distribution in Long-Sleep and Short Sleep Mice. Alcohol 6:33–38
Sunahara GI (1979) Effect of ethanol on stimulated acetylcholine release in vitro from rat cortical and hippocampal tissues. MSc thesis, Department of pharmacology, University of Toronto
Sunahara GI, Kalant H, Schofield M, Grupp L (1978) Regional distribution of ethanol in the rat brain. Can J physiol Pharmacol 56:988–992
Tabakoff B, Ritzmann RF (1979) Acute tolerance in inbred and selected lines of mice. Drug Alcohol Depend 4:87–90
Tabakoff B, Ritzmann RF, Raju TS, Deitrich RA (1980) Characterization of acute and chronic tolerance in mice selected for inherent differences in ethanol sensitivity. Alcohol Clin Exp Res 4:70–73
Tiffany ST, McCal KJ, Maude-Griffin PM (1987) The contribution of classical conditioning to tolerance to the antinociceptive effect of ethanol. Psychopharmacology 92:524–528
Waller MB, McBride WJ, Lumeng L, Li TK (1983) Initial sensitivity and acute tolerance to ethanol in the P and NP lines of rats. Pharmacol Biochem Behav 19:683–686
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Lê, A.D., Mana, M., Quan, B. et al. Differential development of acute tolerance to the motor impairment and anticonvulsant effects of ethanol. Psychopharmacology 109, 107–111 (1992). https://doi.org/10.1007/BF02245487
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DOI: https://doi.org/10.1007/BF02245487