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Influence of nonsteroidal anti-inflammatory compounds on healing of chronic gastric ulcers in rats

  • Histamine and Kinins
  • Histamine and the Gastrointestinal Tract
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Abstract

Pre-treatment with NOSAC led to an increase of ulcer index in a dose-dependent manner indicating the aggravation of gastric lesions under the influence of NOSAC. The severity of mucosal lesions was diminished by lengthening the time between the last day of pre-treatment with NOSAC and the day on which ulcers were induced. When NOSAC were administered after the induction of gastric ulcers, the healing of the latter was significantly delayed.

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References

  1. J.I. Isenberg, Prostaglandins: pharmacologic principles. InAdvances in Ulcer Disease, pp. 416–420 (EdsK.-H. Holtermüller andJ.R. Malagelada). Excerpta Medica, Amsterdam 1980.

    Google Scholar 

  2. C. Johansson andB. Kollberg, E2 prostaglandins—potential agents in peptic ulcer treatment. InAdvances in Ulcer Disease, pp. 421–426 (EdsK.-H. Holtermüller andJ.R. Malagelada). Excerpta Medica, Amsterdam 1980.

    Google Scholar 

  3. K. Takagi, S. Okabe andR. Sazaki,A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing, Japan. J. Pharmacol.19, 418–426 (1970).

    Google Scholar 

  4. D.S. Kahn, M.J. Phillips andS.S. Skoryna,The early penetration of experimental gastric ulcers in rats receiving cortisone, Am. J. Path.38, 73–82 (1961).

    PubMed  Google Scholar 

  5. A. Robert, J.E. Nezamis andJ.P. Philipps,Effect of prostaglandin E 1 on gastric secretion and ulcer formation in the rat, Gastroenterology55, 481–487 (1968).

    PubMed  Google Scholar 

  6. A. Ishibashi, Y. Kasuya, K. Takeuchi andS. Okabe,Effects of 15(S)-15-methyl-PGE 2 methylester on healing of chronic gastric and duodenal ulcers in rats, Japan. J. Pharmacol.29, 807–811 (1979).

    Google Scholar 

  7. S.J. Konturek, T. Radecki, T. Brzozowski, I. Piastucki, A. Dembinska-Kiec andA. Zmuda, Experimental studies on gastric cytoprotection by prostaglandins, antisecretory agents and epidermal growth factor. Inadvances in Ulcer Disease, pp. 78–86 (EdsK.-H. Holtermüller andJ.R. Malagelada). Excerpta Medica, Amsterdam 1980.

    Google Scholar 

  8. D. Müller,Regulation und Beeinflussung der Nucleinsäuresynthese der Magenschleimhaut, Inaug. Diss. Eberhard-Karl-Universität zu Tübingen (1978).

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Authors and Affiliations

  1. Department of Pharmacology, Heumann-Pharma, Heideloffstrasse 18-28, 8500, Nürnberg, Germany

    I. Szelenyi, H. Engler & S. Postius

  2. Department of Biochemistry, Heumann-Pharma, Heideloffstrasse 18-28, 8500, Nürnberg, Germany

    H. Vergin

  3. 1st Department of Medicine, Gutenberg-University, 6500, Mainz, Germany

    P. Herzog & K. -H. Holtermüller

Authors
  1. I. Szelenyi
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  2. H. Engler
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  3. P. Herzog
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  4. S. Postius
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  5. H. Vergin
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  6. K. -H. Holtermüller
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Szelenyi, I., Engler, H., Herzog, P. et al. Influence of nonsteroidal anti-inflammatory compounds on healing of chronic gastric ulcers in rats. Agents and Actions 12, 180–182 (1982). https://doi.org/10.1007/BF01965139

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  • DOI: https://doi.org/10.1007/BF01965139

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