Abstract
Citrinin, a secondary product of fungal metabolism, is nephrotoxic in the rat. Because citrinin is an organic anion, it might be expected to be transported by the renal organic anion transport system. Rat renal cortical slices were used to characterize the transport. 14C-Citrinin uptake was enhanced by lactate and reduced by probenecid, a specific inhibitor of anion transport. Dinitrophenol is a metabolic inhibitor as well as competitive inhibitor of anion transport, and it also reduced citrinin transport. Organic cations did not alter citrinin accumulation by the slices. These data are consistent with the transport of citrinin by the renal organic anion secretory system.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Berndt WO, Beechwood EC (1965) Influence of inorganic electrolytes and ouabain on uric acid transport. Am J Physiol 208: 223–231
Berndt WO, Grote D (1968) The accumulation of 14C-dinitrophenol by slices of rabbit kidney cortex. J Pharmacol Exp Ther 164: 223–231
Berndt WO, Hayes AW (1977) Effects of citrinin on renal tubular transport functions in the rat. J Environ Pathol Toxicol 1: 93–103
Berndt WO, Hayes AW (1981) Effects of nephrotoxic fungal toxins on renal calcium transport. Toxicologist 1: 9
Berndt WO, Hayes AW (1982) The effect of probenecid on citrinin-induced nephrotoxicity. Toxicol Appl Pharmacol 64: 118–124
Chung WT, Park YS, Hong SK (1970) Effect of cations on transport of weak organic acids in rabbit kidney slices. Am J Physiol 219: 30–36
Davis ND, Dalbny DK, Diener UL, Sansing GA (1975) Median scale production of citrinin by Penicillium citrinum in a semisynthetic medium. Appl Microbiol 29: 118–120
Elling F, Moller T (1974) Mycotoxic nephropathy in pigs. Bull WHO 49: 411–418
Gerencser GA, Park YS, Hong SK (1973) Sodium influence upon the transport kinetics of p-aminohippurate in rabbit kidney slices. Proc Soc Exp Biol Med 144: 440–442
Klahr S, Robson AM, Guggenheim SJ, Tateishi S, Bourgoigne JJ, Hwang KH (1970) Ammonium-induced alterations in PAH uptake and cation composition of kidney slices. Am J Physiol 219: 994–1000
Krogh P (1972) Mycotoxic procine nephropathy: A possible model for Balkan endemic nephropathy. Proc. 2nd Int. Symp. on endemic nephropathy (Sofia): 229–270
Krogh P (1976) Epidemiology of mycotoxic procine nephropathy. Nord Bet Med 28: 452–458
Lockard VG, Phillips RD, Hayes AW, Berndt WO, O'Neal RM (1980) Citrinin nephrotoxicity in rats: a light and electron microscopic study. Exp Mol Pathol 32: 226–240
Phillips RD, Berndt WO, Hayes AW (1979) Distribution and excretion of (14C)citrinin in rats. Toxicology 12: 285–298
Phillips RD, Hayes AW, Berndt WO, Williams WL (1980) Effects of citrinin on renal function and structure. Toxicol 16: 123–137
Roch-Ramel F, Weiner IM (1980) Renal urate excretion: Factors determining the action of drugs. Kidney Int 18: 665–676
Roch-Ramel F, White F, Vowels L, Simmonds HA, Cameron JS (1980) Micropuncture study of tubular transport of urate and PAH in the pig kidney. Am J Physiol 239: F107-F112
Scott P (1974) Penicillium mycotoxins. In: Wyllie RD, Morehouse LG (eds) Mycotoxic Fungi, Mycotoxins, Mycotoxicoses, vol 1. Marcel Dekker, Inc., New York
Tune BM, Burg MB, Patlak CS (1969) Characteristics of p-aminohippurate transport in proximal renal tubule. Am J Physiol 207: 1057–1063
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Berndt, W.O. Transport of citrinin by rat renal cortex. Arch Toxicol 54, 35–40 (1983). https://doi.org/10.1007/BF00277813
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF00277813