Abstract
Glomerular visceral epithelial cells, also termed podocytes, are highly specialized epithelial cells that cover the outer aspect of the glomerular basement membrane. Recent studies point to an important role of podocytes in the physiology and pathophysiology of the glomerulus. This review summarizes the structure-function relationships of podocytes. Following a description of the general morphology of podocytes, the technical problems associated with studying these cells are discussed. A survey of podocyte function forms the center of this review. Finally, selected aspects of podocyte development and cell division are discussed.
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Abrahamson DR (1985) Origin of the glomerular basement membrane visualized after in vivo labeling of laminin in newborn rat kidneys. J Cell Biol 100:1988–2000
Abrahamson DR (1987) Structure and development of the glomerular capillary wall and basement membrane. Am J Physiol 253:F783-F794
Abrahamson DR (1991) Glomerulogenesis in the developing kidney. Semin Nephrol 11:375–389
Abrahamson DR, St. John PL, Pillion DJ, Tucker DC (1991) Glomerular development in intraocular and intrarenal grafts of fetal kidneys. Lab Invest 64:629–639
Adler S (1992) Characterization of glomerular epithelial cell matrix receptors. Am J Pathol 141:F571-F578
Adler S, Sharma RM, Savin VJ (1994) Cross-linking of β1, integrins alters glomerular permeability to albumin in isolated glomeruli. J Am Soc Nephrol 5:799
Anderson WP, Alcorn D, Gilchrist AI, Whiting JM, Ryan GB (1989) Glomerular actions of angiotensin II during reduction of renal artery pressure: a morphometric analysis. Am J Physiol 256:F1021-F1026
Andrews PM (1981) Investigations of cytoplasmic contractile and cytoskeletal elements in the kidney glomerulus. Kidney Int 20:549–562
Andrews PM (1988) Morphological alterations of the glomerular (visceral) epithelium in response to pathological and experimental situations. J Electron Micros Tech 9:115–144
Andrews PM, Bates SB (1984) Filamentous actin bundles in the kidney. Anat Rec 210:1–9
Andrews PM, Coffey AK (1980) In vitro studies of kidney glomerular cells. Scanning Electron Microsc 2:179–191
Ardaillou N, Lelongt B, Turner N, Piedagnel R, Boudoin B, Estrade S, Cassingena R, Ronco P (1992) Characterization of a simian virus 40-transformed cell line producing type IV collagen and exhibiting response to atrial natriuretic peptide. J Cell Physiol 152:599–616
Assman KJM, Ronco P, Tangelder MM, Lange WPH, Verroust P, Koene RAP (1989) Involvment of an antigen distinct from the Heymann nephritis antigen in membranous glomerulonephritis in the mouse. Lab Invest 60:138–146
Bachmann S, Kriz W, Kuhn C, Franke WW (1983) Differentiation of cell types of the mammalian kidney by immunofluorescence microcopy using antibodies to intermediate filament proteins and desmoplakins. Histochemistry 77:365–394
Beer J, Masters CL, Beyreuther K (1995) Cell from peripheral tissues that exhibit high APP expression are characterized by their high membrane fusion activity. Neurodegeneration 4:51–59
Bender B, Jaffe R, Carlin B, Chung AE (1981) Immunolocalization of entactin, a sulfated basement membrane component, in rodent tissues, and comparison with GP-2 (laminin). Am J Pathol 103:419–426
Bernstein JF, Cheng F, Roszka BS (1981) Glomerular differentiation in metanephric culture. Lab Invest 45:183–190
Bertram F, Messina A, Dillane PC, Ryan GB (1989) Glomerular podocytes in cultured rat kidney slices. A qualitative and quantitative electron-microscopic study. Cell Tissue Res 256:419–429
Bonadio JF, Sage H, Cheng F, Bernstein J, Striker GE (1984) Localization of collagen types IV and V, laminin, and heparan sulfate proteoglycan to the basal lamina of kidney epithelial cells in transfilter metanephric culture. Am J Pathol 116:289–296
Breiteneder S, Matsui K, Kerjaschki D (1995) Loss of a 43 kDa transmembrane glycoprotein in rat glomerular epithelial cells (GEC) in puromycin aminonucleoside nephrosis. Kidney Int 47:689
Cittanova ML, Chatelet F, Ardaillou N, Galceran M, Verroust P, Ronco P (1992) Identification of a 135 kD protein expressed at the sole of human podocyte foot processes and on the human podocyte clonal cell line HGVEC.SV1A4. J Am Soc Nephrol 3:579
Courtoy PJ, Timpl R, Farquhar MG (1982) Comparative distribution of laminin, type IV collagen, and fibronectin in the rat glomerulus. J Histochem Cytochem 30:874–886
Cybulsky A, Bonventre JV, Quigg RJ, Wolfe LDS, Salant DJ (1990) Extracellular matrix regulates proliferation and phospholipid turnover in glomerular epithelial cells. Am J Physiol, 259:F326-F337
Daniels BS, Deen WM, Mayer G, Meyer T, Hostetter TH (1993) Glomerular permeability barrier in the rat. Functional assessment by in vitro methods. J Clin Invest 92:929–936
Davies M (1994) The mesangial cell: a tissue culture view. Kidney Int 45:320–327
Delarue F, Virone A, Hagege J, Lacave R, Peraldi MN, Aida C, Rondeau E, Feuteun J, Sraer JD (1991) Stable cell line of TSV40 immortalized human glomerular visceral epithelial cells. Kidney Int 40:906–6912
Denton KM, Fennessy PA, Alcorn D, Anderson WP (1992) Morphometric analysis of the actions of angiotensin II on renal arterioles and glomeruli. Am J Physiol 262:F367-F372
Drenckhahn D, Franke RP (1988) Ultrastructural organization of contractile and cytoskeletal proteins in glomerular podocytes of chicken, rat, and man. Lab Invest 59:673–682
Drumond MC, Deen WM (1994) Structural determinants of glomerular hydraulic permeability. Am J Physiol 266:F1-F12
Fish AJ, Michael AF, Vernier RL, Brown DM (1975) Human glomerular cells in tissue culture. Lab Invest 33:330–341
Fries JWU, Sandstrom DJ, Meyer TW, Rennke HG (1989) Glomerular hypertrophy and epithelial cell injury modulate progressive glomerulosclerosis in the rat. Lab Invest 60:205–218
Hancock WW, Atkins RC (1983) Monoclonal antibodies to human glomerular cells: a marker for glomerular epithelial cells. Nephron 33:83–90
Harper PA, Robinson JM, Hoover RL, Wright TC, Karnovsky MJ (1984) Improved methods for culturing rat glomerular cells. Kidney Int 26:875–880
Holthöfer H, Miettinen A, Lehto VP, Lehtonen E, Virtanen I (1984) Expression of vimentin and cytokeratin types of intermediate filament proteins in developing and adult human kidneys. Lab Invest 50:552–559
Holthöfer H, Saino K, Miettinen A (1991) Rat glomerular cells do not express podocytic markers when cultured in vitro. Lab Invest 65:548–557
Hora K, Ohno S, Oguchi H, Furukawa T, Furuta S (1990) Threedimensional study of glomerular slit diaphragm by the quick-freezing and deep-etching replica method. Eur J Cell Biol 53:402–406
Huang TW, Langlois JC (1985) Podoendin. A new cell surface protein of the podocyte and endothelium. J Exp Med 162:245–267
Huber G, Matus A (1990) Microtubule-associated protein 3 (MAP3) expression in non-neuronal tissues. J Cell Sci 95:237–246
Jaremko G, Larsson L, Bohman SO (1989) Angiotensin-induced structural changes in the rat glomerulus. J Ultrastruct Mol Struct Res 100:300–310
Kasinath BS, Maaba MR, Schwartz MM, Lewis EJ (1986) Demonstration of C3 receptors on rat glomerular epithelial cells. Kidney Int 30:852–861
Kawachi H, Abrahamson DR, St John PL, Goldstein DJ, Shia MA, Matsui K, Shimizu F, Salant DJ (1994) Developmental expression of the nephritogenic antigen of monoclonal antibody (mAb) 5–1–6. J Am Soc Nephrol 5:753
Kerjaschki D (1978) Polycation-induced dislocation of slit diaphragms and formation of cell junctions in rat kindey glomeruli. The effects of low temperature, divalent cations, colchicine, and cytochalasin B. Lab Invest 39:430–440
Kerjaschki D (1990) The pathogenesis of membranous glomerulonephritis: from morphology to molecules. Virchows Arch B Cell Pathol 58:253–271
Kerjaschki D (1994) Dysfunctions of cell biological mechanisms of visceral epithelial cells (podocytes) in glomerular diseases. Kidney Int 45:300–313
Kerjaschki D, Farquhar MG (1983) Immunocytochemical localization of the Heymann nephritis antigen (gp330) in glomerular epithelial cells of normal Lewis rats. J Exp Med 157:667–686
Kerjaschki D, Sharkey DJ, Farquhar MG (1984) Identification and characterization of podocalyxin — the major sialoprotein of the renal glomerular epithelial cell. J Cell Biol 98:1591–1596
Kerjaschki D, Poczewski H, Dekan G, Horvat R, Balzar E, Kraft N, Atkins RC (1986) Identification of a major sialoprotein in the glycocalyx of human visceral glomerular epithelial cells. J Clin Invest 78:1142–1149
Kerjaschki D, Horvorka A, Hillemanns P, Pytela R (1989) A β1-integrin receptor for fibronectin in human kidney glomeruli. Am J Immunol 134:481–489
Kloth S, Meyer D, Röckl W, Miettinnen A, Aigner J, Schmidbauer A, Minuth WW (1992) Characterization of an endothelial protein in the developing rabbit kidney. Differentiation 52:79–88
Knittelberger R, Neale TJ (1990) Isolation and characterization of an unique kidney antigen of relevance in human renal disease. Biochem Biophys Res Comun 172:439–445
Korhonen M, Ylänne J, Laitinen L, Virtanen I (1990a) The α1–α6 subunits of integrins are characteristically expressed in distinct segments of developing and adult human nephron. J Cell Biol 111:1245–1254
Korhonen M, Ylänne J, Laitinen L, Virtanen I (1990b) Distribution of β1- and β3 integrins in human fetal and adult kidney. Lab Invest 62:616–625
Kreisberg JI, Hoover RL, Karnovsky MJ (1978) Isolation and characterization of rat glomerular epithelial cells in vitro. Kidney Int 14:21–30
Kriz W, Hackenthal E, Nobiling R, Sakai T, Elger E (1994a) A role for podocytes to counteract capillary wall distension. Kidney Int 45:369–376
Kriz W, Mundel P, Elger M (1994b) The contractile apparatus of podocytes is arranged to counteract GBM expansion. Contrib Nephrol 107:1–9
Kriz W, Hähnel B, Rösner B, Elger M (1994c) Response of podocytes to long-term treatment with basic fibroblast growth factor (bFGF). J Am Soc Nephrol 5:786
Kriz W, Elger M, Nagata M, Kretzler M, Uiker S, Koeppen-Hagemann I, Tenschert S, Lemley K (1994d) The role of podocytes in the development of glomerular sclerosis. Kidney Int 42:S64-S22
Kriz W, Elger M, Mundel P, Lemly K (1995) Structure-stabilizing forces in the glomerular tuft. J Am Soc Nephrol 5:1731–1739
Kurihara H, Anderson MJ, Farquhar MG (1992a) Increased tyrosine phosphorylation accompanies modification of tight junctions between foot processes of glomerular epithelial cells. ASCB Meeting, Denver, Colorado, USA
Kurihara H, Anderson JM, Farquhar MG (1992b) Diversity among tight junctions in rat kidney: glomerular slit diaphragms and endothelial junctions express only one isoform of the tight junction protein ZO-1. Proc Natl Acad Sci USA 89:7075–7079
Kurihara H, Anderson JM, Kerjaschki D, Farquhar MG (1992c) The altered glomerular filtration slits seen in puromycin aminonucleoside nephrosis and protamine sulfate-treated rats contain the tight junction protein ZO-1. Am J Pathol 141:805–816
Lee LK, Pollock AS, Lovett DH (1993) Asymmetric origin of the mature glomerular basement membrane. J Cell Physiol 157:169–177
Locke M, Krishnan N, McMahon JT (1971) A routine method for obtaining high contrast without staining of sections. J Cell Biol 50:540–544
Lütcke A, Jansson S, Parton RG, Chavier P, Valencia A, Huber LA, Lehtonen E, Zerial M (1993) Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization. J Cell Biol 121:55–564
Mbassa G, Elger M, Kriz W (1988) The ultrastructural organization of the basement membrane of Bowman's capsule in the rat renal corpuscle. Cell Tissue Res 253:151–163
McKay K, Striker LJ, Elliot S, Pinkert CA, Brinster R, Striker G (1988) Glomerular epithelial, mesangial, and endothelial cell lines from transgenic mice. Kidney Int 33:677–684
Mendrick DL, Rennke HG (1988) Induction of proteinuria in the rat by a monoclonal antibody against SGP-115/107. Kidney Int 33:818–830
Mendrick DL, Rennke HG, Cotran RS, Springer TA, Abbas KA (1983) Monoclonal antibodies against rat glomerular antigens: production and specificity. Lab Invest 49:107–117
Mentzel S, Van Son JPHF, Dijkman HBPM, Koene RAP, Assmann KJM (1994) Mouse visceral epithelial cells in culture. J Am Soc Nephrol 5:788
Miettinen A, Dekan G, Farquhar MG (1990) Monoclonal antibodies against membrane proteins of the rat glomerulus. Immunochemical specificity and immunofluorescence distribution of the antigens. Am J Pathol 137:929–944
Müller GA, Müller C (1983) Characterization of renal antigens on distinct parts of the human nephron by monoclonal antibodies. Clin Invest 61:893–902
Mundel P, Gilbert P, Kriz W (1991) Podocytes in glomerulus of rat kidney express a characteristic 44 kD protein. J Histochem Cytochem 39:1047–1056
Mundel P, Gambaryan S, Bachmann S, Koesling D, Kriz W (1995) Immunolocalization of soluble guanylyl cyclase subunits in rat kidney. Histochemistry 103:75–79
Mundlos S, Pelletier J, Darveau A, Bachmann M, Winterpacht A, Zabel B (1993) Nuclear localization of the protein encoded by the Wilm's tumor gene WT1 in embryonic and adult tissues. Development 119:1329–1341
Nagata M, Kriz W (1992) Glomerular damage after uninephrectomy in young rats. II. Mechanical stress of podocytes as a pathway to sclerosis. Kidney Int 42:148–160
Nagata M, Yamaguchi Y, Ito K (1993) Loss of mitotic activity and the expression of vimentin in glomerular epithelial cells of developing human kidneys. Anat Embryol 187:275–279
Natori Y, Hayakawa I, Shibata S (1987) Identification of gp108, a pathogenic antigen of Heymann nephritis as dipeptidyl peptidase IV. Clin Exp Immunol 70:434–439
Natori Y, O'Meara YM, Mannig EC, Minto AWM, Levine JS, Weise W, Salant DJ (1992) Production and polarized secretion of basement membrane components by glomerular epithelial cells. Am J Physiol 262:F131-F137
Nayak R, Attawia MA, Cahili CJ, King GL, Ohashi H, Moromisato R (1992) Expression of a monoclonal antibody (3G5) defined ganglioside antigen in the renal cortex. Kidney Int 41:1638–1645
Nitta K, Uchida A, Kawashima S, Horita T, Tsutsui H, Ozu H, Yumura W, Nihei H (1993) The role of a novel 30 kD protein in human podocytes: special relevance to proteinuria in glomerulonephritis. Jpn J Nephrol 35:1–7
Noorgaard JOR (1978) Retraction of epithelial foot processes during culture of isolated glomeruli. Lab Invest 38:320–329
Noorgaard JOR (1983) Cellular outgrowth from isolated glomeruli. Origin and characterization. Lab Invest 48:526–542
Noorgaard JOR (1987) Rat glomerular epithelial cells in culture. Parietal or visceral epithelial origin? Lab Invest 57:277–290
Ohno S, Hora K, Furukawa T, Oguchi H (1992) Ultrastructural study of the glomerular slit diaphragm in fresh unfixed kidneys by a quick-freezing method. Virch Arch B Cell Pathol 61:351–358
Oosterwijk E, Van Muijen GNP, Oosterwijk-Wakka JC, Warnaar SO (1990) Expression of intermediate-size filaments in developing and adult human kidney and in renal cell carcinoma. J Histochem Cytochem 38:385–392
Orci L, Brown D, Amherdt A, Perrelet A (1982) Distribution of intramembrane particles and filipin-sterol complexes in plasma membranes of kidney. I. Corpuscle of Malphigi. Lab Invest 46:545–553
Orikasa M, Matsui K, Oite T, Shimizu F (1988) Massive proteinuria induced in rats by a single injection of a monoclonal antibody. J Immunol 141:807–814
Ozaki I, Ito Y, Fukatsu A, Suzuki N, Yoshida F, Watanabe Y, Sakamoto N, Masou S (1990) A plasma membrane antigen of rat glomerular epithelial cells. Antigenic determinants involving N-linke sugar residues in a 140 kilodalton sialoglycoprotein of the podocytes. Lab Invest 63:707–716
Pabst R, Sterzel RB (1983) Cell renewal of glomerular cells -in normal rats. An autoradiographic analysis. Kidney Int 24:626–631
Parysek LM, Wolosewick JJ, Olmsted JB (1984) MAP 4: a microtubule-associated protein specific for a subset of tissue microtubules. J Cell Biol 99:2287–2296
Pavenstädt H, Späth M, Schlunk G, Nauck M, Fischer R, Wanner C, Schollmeyer P (1992) Effects of nucleotides on the cytoslic free calcium activity and inositol phosphate formation in human glomerular epithelial cells. Br J Pharmacol 107:189–195
Platt JL, Tucker WL, Michael AF (1983) Stages of renal ontogenesis identified by monoclonal antibodies reactive with lymphohematopoetic differentiation antigens. J Exp Med 157:155–172
Quigg R, Sneed AE (1994) Molecular characterization of rat glomerular epithelial cell complement receptors. J Am Soc Nephrol 4:1912–1919
Quigg RJ, Cybulsky AV, Jacobs JB, Salant DJ (1988) Anti Fx1A produces complement-dependent cytotoxicity of glomerular epithelial cells. Kidney Int 34:43–52
Rasch R, Noorgaard JOR (1983) Renal enlargement: comparative autoradiographic studies of 3H-thymidine uptake in diabetic and uninephrectomized rats. Diabetologica 25:280–287
Reeves W, Caulfield JP, Farquhar MG (1978) Differentiation of epithelial foot processes and filtation slits. Sequential appearance of occluding junctions, epithelial polyanion, and slit membranes in developing glomeruli. Lab Invest 39:90–100
Reeves W, Kanwar YS, Farquhar MG (1980) Assembly of the glomerular filtation surface. Differentiation of anionic sites in glomerular capillaries of newborn rat kidney. J Cell Biol 85:735–753
Reivinen J, Holthöfer H, Miettinen A (1992) A cell-type specific ganglioside of glomerular podocytes in rat kidney: an O-acetylated GD3. Kidney Int 42:624–631
Rodewald R, Karnovsky MJ (1974) Porous substructure of the glomerular slit diaphragm in the rat and mouse. J Cell Biol 60:423–433
Sakai T, Kriz W (1987) The structural relationship between mesangial cells and basement membrane of the renal glomerulus. Anat Embryol 176:373–386
Sakai T, Sabanovic S, Hosser H, Kriz W (1986) Heterogeneity of the podocyte membrane in rat kidney as revealed by ethanol dehydration of unosmicated specimens. Cell Tissue Res 246:145–151
Sariola H, Ekblom P, Lehtonen E, Saxen L (1983) Differentiation and vascularization of the metanephric kidney grafted on the chorioallantoic membrane. Dev Biol 96:427–435
Sariola H, Timpl R, Van der Mark K, Mayne R, Fitch JM, Linsenmayer TF, Ekblom P (1984) Dual origin of the glomerular basement membrane. Dev Biol 101:86–96
Saxen L (1987) Organogenesis of the kidney. In: Barlow PW, Green PB, Wylie CC (eds) Developmental and cell biology series. Cambridge University Press, Cambridge, pp 1–165
Schnabel E, Miettinen A, Dekan G, Farquhar MG (1989) Biogenesis of podocalyxin — the major glomerular sialoglycoprotein in the newborn rat kidney. Eur J Cell Biol 48:313–326
Schnabel E, Anderson MA, Farquhar MG (1990) The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium. J Cell Biol 111:1255–1263
Seiler MW, Rennke HG, Venkatachalam MA, Cotran RS (1977) Pathogenesis of polycation-induced alterations (“fusion”) of glomerular epithelium. Lab Invest 36:48–61
Shake JG, Brandt RC, Daniels BS (1992) Angiotensin II induces actin polymerization within the glomerular filtration barrier: possible role in the local regulation of ultrafiltration. J Am Soc Nephrol 3:568
Sharma R, Lovell HB, Wiegmann TB, Savin VJ (1992) Vasoactive substances induce cytoskeletal changes in cultured rat glomerular epithelial cells. J Am Soc Nephrol 3:1131–1138
Shin ML, Gelfand MC, Nagle RB, Carlo JR, Green I, Frank MM (1977) Localization of receptors for activated complement on visceral epithelial cells of the human renal glomerulus. J Immunol 118:869–873
Sorokin L, Ekblom P (1992) Development of tubular and glomerular cells of the kidney. Kidney Int 41:657–664
Stow JL, Sawada H, Farquhar MG (1985) Basement membrane heparan sulfate proteoglycans are concentrated in the laminae rarae and in podocytes of the rat renal glomerulus. Proc Natl Acad Sci USA 82:3296–3330
Stow JL, Soroka CJ, McKay K, Sriker L, Striker GE, Farquhar MG (1989) Basement membrane heparan sulfate proteoglycan is the main proteoglycan synthesized by glomerular epithelial cells in culture. Am J Pathol 135:637–646
Striker GE, Savin V, Agodoa L, Killen PD (1976) Glomerular cells in vitro. Contrib Nephrol 2:25–34
Striker GE, Killen PD, Farin FM (1980) Human glomerular cells in vitro: isolation and characterization. Transplant Proc 12:88–99
Thomas GJ, Jenner L, Mason RM, Davies M (1990) Human glomerular epithelial cell proteoglycans. Arch Biochem Biophys 278:11–20
Thomas PE, Goval B, Wharren J, Wiggins EK, Bjornsted D, Wiggins R (1992) Molecular cloning of rabbit podocalyxin. J Am Soc Nephrol 3:782
Thomas PE, Wharram BL, Goyal M, Wiggins JE, Holzman LB, Wiggins RC (1994) GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit. J Biol Chem 269:19953–19962
Tissari J, Holthöfer M, Miettinen A (1994) Novel 13A antigen is an integral protein of the basolateral membrane of rat glomerular podocytes. Lab Invest 71:519–527
Trenchev P, Dorling J, Webb J, Holborow EJ (1976) Localization of smooth muscle-like contractile proteins in kidney by immunoelectron microscopy. J Anat 121:85–95
Vainio S, Lehtonen E, Jalkanen M, Bernfiled M, Saxen L (1989) Epithelial-mesenchymal interactions regulate the stage-specific expression of a cell surface proteoglycan, syndecan, in the developing kidney. Dev Biol 134:382–391
Van der Woude F, Michael AF, Muller E, Van der Hem GK, Vernier RL, Kim Y (1989) Lymphohematopoetic antigens of cultured human glomerular epithelial cells. Br J Exp Pathol 70:73–82
Vasmant D, Maurice M, Feldmann G (1984) Cytoskeletal ultrastructure of podocytes and glomerular endothelial cells in man and in the rat. Anat Rec 210:17–24
Verroust P, Ronco PM, Chatelet F (1986) Monoclonal antibodies and identification of glomerular antigens. Kidney Int 30:649–655
Weinstein T, Cameron R, Katz A, Silverman M (1992) Rat glomerular epithelial cells in culture express characteristics of parietal, not visceral, epithelium. J Am Soc Nephrol 3:1279–1287
Whiteside C, Prutis K, Cameron R, Thompson J (1989) Glomerular epithelial detachment, not reduced charge densitiy, correlates with proteinuria in adriamycin and puromycin nephrosis. Lab Invest 61:650–660
Yamada H, Sexton PM, Chai SY, Adam WR, Mendelsohn FA (1990) Angiotensin II receptors in the kidney. Localization and physiological significance. Am J Hypertens 3:250–255
Yamamoto T, Fengl L, Mizuno T, Hirose S, Kawasaki K, Yaoita E, Kihara I, Wilson CB (1994) Expression of mRNA for natriuretic peptide receptor subtypes in bovine kidney. Am J Physiol 267:F318-F324
Yaoita E, Kawasaki K, Yamamoto T, Kihara I (1990) Variable expression of desmin in rat glomerular epithelial cells. Am J Pathol 136:899–908
Yaoita E, Yamamoto T, Saito M, Kawasaki K, Kihara I (1991) Desmin-positive epithelial cells outgrowing from rat encapsulated glomeruli. Eur J Cell Biol 54:140–149
Zhao J, Ardaillou N, Lu CY, Placier S, Pham P, Badre L, Cambar J, Ardaillou R (1994) Characterization of C-type natriuretic peptide receptors in human mesangial cells. Kidney Int 46:717–725
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Mundel, P., Kriz, W. Structure and function of podocytes: an update. Anat Embryol 192, 385–397 (1995). https://doi.org/10.1007/BF00240371
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DOI: https://doi.org/10.1007/BF00240371